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Pharmacokinetics of Succinate in Rats after Intravenous Administration of Mexidol

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The pharmacokinetics of succinate was studied in Wistar rats after a single intravenous administration of Mexidol in a dose 100 mg/kg body weight. The concentration of succinate in blood plasma, cytoplasmic and mitochondrial fractions of cells of the cerebral cortex, left-ventricular myocardium, and liver was measured by HPLC-MS/MS. After single intravenous administration of Mexidol, succinate was evenly distributed in organs and tissues and quickly eliminated from the body. The pharmacokinetics of succinate was described by a two-chamber model. An increase in the level of succinate in the cytoplasmic fraction of the liver, myocardium, and cerebral cortex cells and a minor increase in the mitochondrial fraction were observed. The maximum increase in the level of succinate in the cytoplasmic fraction was observed in the liver tissue, a less pronounced elevation was observed in the cerebral cortex and myocardium; no significant differences between the cerebral cortex and myocardium were observed by this parameter.

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Authors and Affiliations

  1. Ryazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia

    A. V. Shchulkin, P. Yu. Mylnikov, I. V. Chernykh, A. S. Esenina & E. N. Yakusheva

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  1. A. V. Shchulkin
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  2. P. Yu. Mylnikov
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  3. I. V. Chernykh
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  4. A. S. Esenina
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  5. E. N. Yakusheva
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Correspondence to A. V. Shchulkin.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 1, pp. 65-69, January, 2023

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Shchulkin, A.V., Mylnikov, P.Y., Chernykh, I.V. et al. Pharmacokinetics of Succinate in Rats after Intravenous Administration of Mexidol. Bull Exp Biol Med 175, 54–58 (2023). https://doi.org/10.1007/s10517-023-05810-5

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  • DOI: https://doi.org/10.1007/s10517-023-05810-5

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