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Effect of Glycyrrhetic Acid Derivatives on Regulation of Thymocyte Volume

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We studied the effects of glycyrrhetinic acid (bioactive aglycone of glycyrrhizin) and its ester derivatives at positions C-3 and C-30 on the cell volume regulation in rat thymocytes under conditions of hypoosmotic stress. Native glycyrrhetinic acid completely suppressed this process with half-maximal concentration of 12.7±1.4 μM and Hill coefficient of 3.1±0.6. Formation of esters at C-3 (esters with the acetic, cinnamic and methoxi-cinnamic acid) and at C-30 (methyl ester) drastically decreased the inhibitory activity of the molecule, suggesting that intact hydroxyl group at C-3 and carboxyl group at C-30 are structurally important determinants of biological activity of glycyrrhetinic acid towards volume regulation of thymic lymphocytes.

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Authors and Affiliations

  1. Institute of Biophysics and Biochemistry, Mirzo Ulugbek National Uzbekistan University, Tashkent, Republic of Uzbekistan

    M. B. Rakhimova, P. G. Merzlyak, R. Sh. Kurbannazarova & R. Z. Sabirov

  2. Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Republic of Uzbekistan

    R. S. Esanov, M. B. Gafurov & O. D. Matchanov

Authors
  1. M. B. Rakhimova
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  2. R. S. Esanov
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  3. P. G. Merzlyak
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  4. M. B. Gafurov
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  5. R. Sh. Kurbannazarova
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  6. O. D. Matchanov
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  7. R. Z. Sabirov
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Corresponding author

Correspondence to R. Z. Sabirov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 1, pp. 34-38, January, 2023

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Rakhimova, M.B., Esanov, R.S., Merzlyak, P.G. et al. Effect of Glycyrrhetic Acid Derivatives on Regulation of Thymocyte Volume. Bull Exp Biol Med 175, 27–31 (2023). https://doi.org/10.1007/s10517-023-05804-3

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  • DOI: https://doi.org/10.1007/s10517-023-05804-3

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