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Regulation of Human Platelet Adhesion with Ascorbic Acid

  • MORPHOLOGY AND PATHOMORPHOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Morphofunctional characteristics of human platelets in the presence of 0.1-5 mM ascorbic acid were studied. The platelet ability to form lamellae and the preservation of granules in platelets in suspension and during adhesion were evaluated. Ascorbic acid in concentrations of 0.1-1 mM induced no visible changes in platelet structure and did not affect their adhesion activity, but suppressed lamella growth and degranulation in adherent platelets in a dose-dependent manner. The maximum preservation of granules was revealed in the presence of 0.5 mM ascorbic acid (55% in 1 h from the moment of adhesion). In the presence of 2-5 mM ascorbic acid, spontaneous activation and degranulation of platelets was observed. Thus, ascorbic acid is capable of both suppressing and stimulating platelet activity. In concentrations of 0.5-1 mM ascorbic acid can be used to stabilize granules in adherent platelets.

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Authors and Affiliations

  1. N. V. Sklifosovsky Research Institute of Emergency Medicine, Moscow Health Department, Moscow, Russia

    M. S. Makarov & M. V. Storozheva

Authors
  1. M. S. Makarov
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  2. M. V. Storozheva
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Correspondence to M. S. Makarov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 8, pp. 253-256, August, 2022

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Makarov, M.S., Storozheva, M.V. Regulation of Human Platelet Adhesion with Ascorbic Acid. Bull Exp Biol Med 174, 280–282 (2022). https://doi.org/10.1007/s10517-023-05690-9

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  • DOI: https://doi.org/10.1007/s10517-023-05690-9

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