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Influence of Humic Acids Isolated from Raised Bog Sphagnum Peat on Development of Th1/Th2 Immune Response

  • IMMUNOLOGY AND MICROBIOLOGY
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The course administration of humic acids isolated with sodium pyrophosphate from raised bog sphagnum peat reduces the parameters of a Th1-type immune response in C57BL/6 mice, the severity of an anaphylactic shock in outbred CD1 mice, and degranulation of mast cells after their immunization with ovalbumin. The addition of humic acids increases the stimulated production of IL-4, IL-10 and reduces the production of IL-2, IFNγ by peripheral blood mononuclear cells of healthy donors.

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References

  1. Zhu J, Yamane H, Paul WE. Differentiation of effector CD4 T cell populations (*). Annu. Rev. Immunol. 2010;28:445-489. doi: https://doi.org/10.1146/annurev-immunol-030409-101212

    Article  CAS  Google Scholar 

  2. Raphael I, Nalawade S, Eagar TN, Forsthuber TG. T cell subsets and their signature cytokines in autoimmune and inflammatory diseases. Cytokine. 2015;74(1):5-17. doi: https://doi.org/10.1016/j.cyto.2014.09.011

    Article  CAS  Google Scholar 

  3. Chaplin DD. Overview of the immune response. J. Allergy Clin. Immunol. 2010;125(2, Suppl. 2.):S3-23. doi: https://doi.org/10.1016/j.jaci.2009.12.980

  4. Anthony RM, Rutitzky LI, Urban JF Jr, Stadecker MJ, Gause WC. Protective immune mechanisms in helminth infection. Nat. Rev. Immunol. 2007;7(12):975-987. doi: https://doi.org/10.1038/nri2199

    Article  CAS  Google Scholar 

  5. Popov AI. Humic Compounds: Properties, Structure, and Formation. St. Petersburg, 2004. Russian.

  6. Trofimova ES, Zykova MV, Danilets MG, Ligacheva AA, Sherstoboev EY, Tsupko AV, Mikhalyov DA, Belousov MV. Immunomodulating Properties of Humic Acids Extracted from Oligotrophic Sphagnum magellanicum Peat. Bull. Exp. Biol. Med. 2021;170(4):461-465. doi: https://doi.org/10.1007/s10517-021-05088-5

    Article  CAS  Google Scholar 

  7. van Rensburg CE, Naude PJ. Potassium humate inhibits complement activation and the production of inflammatory cytokines in vitro. Inflammation. 2009;32(4):270-276. doi: https://doi.org/10.1007/s10753-009-9130-6

    Article  CAS  Google Scholar 

  8. Cagno V, Donalisio M, Civra A, Cagliero C, Rubiolo P, Lembo D. In vitro evaluation of the antiviral properties of Shilajit and investigation of its mechanisms of action. J. Ethnopharmacol. 2015;166:129-134. doi: https://doi.org/10.1016/j.jep.2015.03.019

    Article  Google Scholar 

  9. Radomska-Leśniewska DM, Skopińska-Różewska E, Jóźwiak J, Demkow U, Joanna Bałan B. Angiomodulatory properties of some antibiotics and Tołpa Peat Preparation. Cent. Eur. J. Immunol. 2016;41(1):19-24. doi: https://doi.org/10.5114/ceji.2016.58312

    Article  CAS  Google Scholar 

  10. Zykova MV, Schepetkin IA, Belousov MV, Krivoshchekov SV, Logvinova LA, Bratishko KA, Yusubov MS, Romanenko SV, Quinn MT. Physicochemical Characterization and Antioxidant Activity of Humic Acids Isolated from Peat of Various Origins. Molecules. 2018;23(4):753. doi: https://doi.org/10.3390/molecules23040753

    Article  CAS  Google Scholar 

  11. Kovalenko LP, Fedoseeva VN, Durnev AD, Ivanova AS, Maternak TB, Mironov AN, Arzamastsev EV, Gus’kova TA, Zhogoleva IB, Verstakova OL, Radchenko LU. Methodical recommendations for the study of drugs with allergizing effect. Manual for Preclinical Studies of New Pharmacological Substances. Mironov AN, ed. Moscow, 2013. P. 51-63. Russian.

  12. Khaitov RM, Gushchin IS, Pinegin BV, Yarilin AA, Mironov AN, Merculov VA, Kozhinova EV. Methodical recommendations for the study of immunotropic activity of drugs. Manual for Preclinical Studies of New Pharmacological Substances. Mironov AN, ed. Moscow, 2013. P. 626-641. Russian.

  13. Belska NV, Danilets MG, Belsky YP, Trophimova ES, Utchasova EG, Borsuk OS, Agaphonov VI. Modelling of an anaphylaxis using BALb/c mice. Biomeditsina. 2010;1(1):37-50. Russian.

    Google Scholar 

  14. Uzzaman A, Cho SH. Chapter 28: Classification of hypersensitivity reactions. Allergy Asthma Proc. 2012;33(Suppl 1):96-99. doi: https://doi.org/10.2500/aap.2012.33.3561

    Article  Google Scholar 

  15. Na H, Cho M, Chung Y. Regulation of Th2 Cell Immunity by Dendritic Cells. Immune Netw. 2016;16(1):1-12. doi: https://doi.org/10.4110/in.2016.16.1.1

    Article  Google Scholar 

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    E. S. Trofimova, E. Yu. Sherstoboev, M. G. Danilets & A. A. Ligacheva

  2. Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    E. S. Trofimova, M. V. Zykova & M. V. Belousov

Authors
  1. E. S. Trofimova
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  2. M. V. Zykova
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  3. E. Yu. Sherstoboev
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  4. M. G. Danilets
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  5. A. A. Ligacheva
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  6. M. V. Belousov
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Corresponding author

Correspondence to E. S. Trofimova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 8, pp. 201-206, August, 2022

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Trofimova, E.S., Zykova, M.V., Sherstoboev, E.Y. et al. Influence of Humic Acids Isolated from Raised Bog Sphagnum Peat on Development of Th1/Th2 Immune Response. Bull Exp Biol Med 174, 236–240 (2022). https://doi.org/10.1007/s10517-023-05680-x

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  • DOI: https://doi.org/10.1007/s10517-023-05680-x

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