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The Effect of α2-Adrenoreceptors Blockade on the Isolated Rat Heart during the Formation of Sympathetic Innervation

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We studied the effects of the α2-adrenergic receptor antagonist yohimbine (10–9-10–6 M) on inotropy, chronotropy, and coronary flow in the Langendorff-isolated heart from 3- and 6-week-old rats. Yohimbine affected all the studied functional parameters of the isolated heart. The force of contraction of the left ventricular myocardium, HR, and coronary flow decreased at all studied concentrations of the antagonist. The maximum chronotropic effect was observed in the heart from 6-week-old rats in the presence of 10–6 M yohimbine in the perfused solution and in the heart from 3-week-old rats in the presence of 10–9 M yohimbine. The minimum chronotropic and inotropic effect was recorded in the hearts from 6-week-old animals after application of 10–9 M α2-adrenergic receptor blocker and in the hearts from 3-week-old animals at yohimbine concentration of 10–7 M. The least pronounced decrease in coronary flow in 3- and 6-week-old rats was observed at the minimum concentration of yohimbine.

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Authors and Affiliations

  1. Department of Human Health Protection, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia

    T. L. Zefirov, L. I. Khisamieva, A. M. Kuptsova & N. I. Ziyatdinova

  2. Department of Normal Physiology, Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Republic of Tatarstan, Russia

    A. L. Zefirov

Authors
  1. T. L. Zefirov
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  2. L. I. Khisamieva
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  3. A. M. Kuptsova
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  4. N. I. Ziyatdinova
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  5. A. L. Zefirov
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Correspondence to T. L. Zefirov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 8, pp. 190-193, August, 2022

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Zefirov, T.L., Khisamieva, L.I., Kuptsova, A.M. et al. The Effect of α2-Adrenoreceptors Blockade on the Isolated Rat Heart during the Formation of Sympathetic Innervation. Bull Exp Biol Med 174, 226–229 (2022). https://doi.org/10.1007/s10517-023-05678-5

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  • DOI: https://doi.org/10.1007/s10517-023-05678-5

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