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Response of Isolated Rat Heart to α2-Adrenergic Receptor Stimulation after If Current Blockade in the Late Postinfarction Period

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We studied the effect of α2-adrenoreceptor activation after preliminary If-current blockade on the performance of the Langendorff-isolated rat heart 54 days after modeling myocardial infarction. Stimulation of α2-adrenoreceptors against the background of application of If blocker ZD7288 in concentrations of 10—9 and 10—5 M decreased myocardial inotropy in isolated rat hearts by 50 and 39% (p<0.05) and increased HR by 20 and 15% (p<0.05), respectively. Activation of α2-adrenoreceptors against the background of application of ZD7288 in a concentration of 10—9 and 10—5 M led to a decrease in the coronary flow in the isolated rat heart with the model of myocardial infarction by 21% (p<0.05) and 32% (p<0.05), respectively.

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Authors and Affiliations

  1. Department of Human Health Protection, Kazan (Volga region) State University, Kazan, Republic of Tatarstan, Russia

    R. K. Bugrov, A. M. Kuptsova, N. I. Ziyatdinova & T. L. Zefrov

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  1. R. K. Bugrov
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  2. A. M. Kuptsova
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  3. N. I. Ziyatdinova
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  4. T. L. Zefrov
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Correspondence to T. L. Zefrov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 7, pp. 28-32, July, 2022

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Bugrov, R.K., Kuptsova, A.M., Ziyatdinova, N.I. et al. Response of Isolated Rat Heart to α2-Adrenergic Receptor Stimulation after If Current Blockade in the Late Postinfarction Period. Bull Exp Biol Med 174, 22–25 (2022). https://doi.org/10.1007/s10517-022-05640-x

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  • DOI: https://doi.org/10.1007/s10517-022-05640-x

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