We studied the effect of antioxidants dibornol (2,6-diisobornyl-4-methylphenol) and its derivative (4-hydroxymethyl-2,6-diisobornylphenol), members of the alkylated phenols group, on the redox potential of male germ cells and their morphological and functional state in the rat model of pathospermia. Pharmacological effect was observed in animals treated with dibornol. The studied compounds led to the normalization of the antioxidant—prooxidant balance. However, the value of this indicator against the background of treatment with dibornol derivative attested to a shift in the redox balance of cells towards reduction reactions.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility. World J. Mens Health. 2019;37(3):296-312. doi: https://doi.org/10.5534/wjmh.190055
Evans EPP, Scholten JTM, Mzyk A, Reyes-San-Martin C, Llumbet AE, Hamoh T, Arts EGJM, Schirhagl R, Cantineau AEP. Male subfertility and oxidative stress. Redox Biol. 2021;46:102071. doi: https://doi.org/10.1016/j.redox.2021.102071
Symeonidis EN, Evgeni E, Palapelas V, Koumasi D, Pyrgidis N, Sokolakis I, Hatzichristodoulou G, Tsiampali C, Mykoniatis I, Zachariou A, Sofikitis N, Kaltsas A, Dimitriadis F. Redox Balance in male infertility: Excellence through Moderation — “Μέτρον ριστον”. Antioxidants (Basel). 2021;10(10):1534. doi: https://doi.org/10.3390/antiox10101534
Men’shchikova YB, Lankin VZ, Kandalintseva NV. Phenolic Antioxidants in Biology and Medicine. Saarbrücken, 2012.
Borovskaya TG, Kamalova SI, Krivova NA, Zaeva OB, Poluektova ME, Vychuzhanina AV, Grigor’eva VA, Plotnikov MB, Goldberg VE. Experimental study of the effectiveness of phenolic antioxidants in male infertility caused by pathospermia. Bull. Exp. Biol. Med. 2018;166(1):7-10. doi: https://doi.org/10.1007/s10517-018-4276-6
Shevchenko OG, Plyusnina SN, Buravlev EV, Chukicheva IYu, Fedorova IV, Shchukina OV, Kutchin AV. Structure—hemolytic activity relationship in isobornylphenol derivatives. Russ. Chem. Bull. 2017;66(10):1881-1890. doi: https://doi.org/10.1007/s11172-017-1962-x
Borovskaya TG, Kamalova SI, Kuchin AV, Chukicheva IYu, Buravlev EV, Krivova NA, Zaeva OB, Vychuzhanina AV, Shchemerova YuA, Grigorieva VA., Neplokhov E.A., Vasilevsky R.P., Poluektova M.E. Experimental evaluation of the influence of isobornylphenols on the development of BPH and the redox potential of prostate cells. Exper. Klin. Urol. 2021;14(3):18-26. Russian. doi: https://doi.org/10.29188/2222-8543-2021-14-3-18-26
Durnev AD, Smol’nikova NM, Skosyreva AM, Nemova EP, Solomina AS, Shreder OV, Gus’kova TA, Verstakova OL, Syubaev RD. Methodological recommendations for preclinical study of reproductive toxicity of new drugs. Manual for Preclinical Studies of New Pharmacological Substances. Part I, Mironov AN, ed. Moscow, 2012. Part 1. P. 80-93. Russian.
Muller CH, Lee TK, Montaño MA. Improved chemiluminescence assay for measuring antioxidant capacity of seminal plasma. Methods Mol. Biol. 2013;927:363-376. doi: https://doi.org/10.1007/978-1-62703-038-0_31
Aristova NA, Ivanova IP, Trofimova SV, Knyazev DI, Piskarev IM. Infliuence of Luminol on the Chemiluminescence Intensity in Fenton Reaction. Issled. Rossii. 2011:77-86. Russian.
Goldberg ED, Borovskaya TG. Gonadotoxic Effects of Anticancer Drugs. Tomsk, 2000. Russian.
Steiner AZ, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Coward RM, Huang H, Wild R, Masson P, Smith JF, Santoro N, Eisenberg E, Zhang H; Reproductive Medicine Network. The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. Fertil. Steril. 2020;113(3):552-560.e3. doi: https://doi.org/10.1016/j.fertnstert.2019.11.008
Li G, Zhang P, You Y, Chen D, Cai J, Ma Z, Huang X, Chang D. Qiangjing tablets regulate apoptosis and oxidative stress via Keap/Nrf2 pathway to improve the reproductive function in asthenospermia rats. Front. Pharmacol. 2021;12:714892. doi: https://doi.org/10.3389/fphar.2021.714892
Tkachev VO, Menshchikova EB, Zenkov NK. Mechanism of the NRF2/KEAP1/ARE signaling system. Biochemistry. 2011;76(4):407-422. doi: https://doi.org/10.1134/S0006297911040031
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 173, No. 6, pp. 697-702, June, 2022
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Borovskaya, T.G., Vychuzhanina, A.V., Shchemerova, Y.A. et al. Experimental Evaluation of the Effectiveness of Isobornylphenols in the Model of Pathospermia and Their Effect on the Antioxidant—Prooxidant Balance of Male Germ Cells. Bull Exp Biol Med 173, 714–718 (2022). https://doi.org/10.1007/s10517-022-05618-9
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-022-05618-9