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Effect of Photodynamic Therapy on the microRNA Level in Breast Cancer Tissues of Female Wistar Rats

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The expression of microRNA (miR-21, miR-221, miR-27a, and miR-429) was studied normal and tumor breast tissues of female Wistar rats before and after photodynamic therapy. In breast cancer, the levels of oncogenic microRNA (miR-21, miR-221, and miR-27a) were increased, while the level of tumor-suppressing miR-429 was reduced in comparison with the intact group. After photodynamic therapy, suppression of the expression levels of oncogenic microRNAs (miR-21, miR-221, and miR-27a) was noted. The level of tumor-suppressing miR-429 in breast tumor tissues remained reduced, as in the untreated breast cancer group.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology — Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    O. V. Kazakov, A. V. Kabakov, A. F. Poveshchenko & V. I. Konenkov

  2. Research Institute of Molecular Biology and Biophysics — Structural Subdivision of the Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia

    V. V. Kononchuk, D. N. Strunkin & L. F. Gulyaeva

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  1. O. V. Kazakov
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  2. A. V. Kabakov
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  3. A. F. Poveshchenko
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  4. V. V. Kononchuk
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  5. D. N. Strunkin
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  6. L. F. Gulyaeva
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  7. V. I. Konenkov
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Correspondence to O. V. Kazakov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 173, No. 4, pp. 452-455, April, 2022

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Kazakov, O.V., Kabakov, A.V., Poveshchenko, A.F. et al. Effect of Photodynamic Therapy on the microRNA Level in Breast Cancer Tissues of Female Wistar Rats. Bull Exp Biol Med 173, 444–447 (2022). https://doi.org/10.1007/s10517-022-05584-2

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  • DOI: https://doi.org/10.1007/s10517-022-05584-2

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