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Correlation of the Levels of microRNA with Cell Composition of Axillary Lymph Node in Wistar Rats with Breast Cancer

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We studied the levels microRNA (miR-21, miR-221, miR-222, and miR-429) in blood serum, thoracic duct lymph, and breast cancer tissue, as well as the cell composition of the axillary lymph node in Wistar female rats with chemically induced breast cancer. The levels of miR-221 and miR-429 in the tumor tissue and in the lymph correlated with the decrease in lymphocyte number in the medullary cords of the axillary lymph nodes.

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References

  1. Grishina KA, Khaylenko VA, Khaylenko DV, Karpukhin AV. Role of microRNAs in breast cancer development and their potential as biomarkers. Opukholi Zhen. Reprod. System. 2018;15(3):40-47. Russian.

  2. Kuznetsov AV. A new method of lymph collection in animals. Bull. Exp. Biol. Med. 1993;116(9):1179-1181.

    Article  Google Scholar 

  3. Nozdrachev AD, Polyakov EL. Rat’s Anatomy. St-Petersburg, 2001. Russian.

  4. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin D.M, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer. 2015;136(5):E359-E386.

  5. Harikai N, Fujii T, Onodera S, Tashiro S. Increases in plasma dihydroxyphenylacetic acid levels in decapitated mice after exposure to various stresses. Biol. Pharm. Bull. 2002;25(7):823- 826.

    Article  CAS  Google Scholar 

  6. Li Z, Branham WS, Dial SL, Wang Y, Guo L, Shi L, Chen T. Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea. BMC Genomics. 2010;11. ID 609. doi: https://doi.org/10.1186/1471-2164-11-609

  7. Waters PS, McDermott AM, Wall D, Heneghan HM, Miller N, Newell J, Kerin MJ, Dwyer RM. Relationship between circulating and tissue microRNAs in a murine model of breast cancer. PLoS One. 2012;7(11). ID e50459. doi:https://doi.org/10.1371/journal.pone.0050459

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Novosibirsk, Russia

    A. V. Kabakov, A. P. Lykov, O. V. Kazakov, A. F. Poveshchenko, O. V. Poveshchenko, I. I. Kim, N. A. Bondarenko, D. N. Strunkin, A. Yu. Letyagin & V. I. Konenkov

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  1. A. V. Kabakov
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  2. A. P. Lykov
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  3. O. V. Kazakov
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  4. A. F. Poveshchenko
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  5. O. V. Poveshchenko
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  6. I. I. Kim
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  7. N. A. Bondarenko
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  8. D. N. Strunkin
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  9. A. Yu. Letyagin
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  10. V. I. Konenkov
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Corresponding author

Correspondence to A. V. Kabakov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 10, pp. 488-490, October, 2019

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Kabakov, A.V., Lykov, A.P., Kazakov, O.V. et al. Correlation of the Levels of microRNA with Cell Composition of Axillary Lymph Node in Wistar Rats with Breast Cancer. Bull Exp Biol Med 168, 500–502 (2020). https://doi.org/10.1007/s10517-020-04740-w

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  • DOI: https://doi.org/10.1007/s10517-020-04740-w

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