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Specific Antibodies to the Fragments of Meningococcal IgA1 Protease during the Formation of Immunity to Bacterial Infections

  • IMMUNOLOGY AND MICROBIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

A Correction to this article was published on 01 September 2022

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The features of individual fragments of IgA1 protease of Neisseria meningitidis serogroup B during the formation of immunity to bacterial infections in animals and humans were studied. The antibodies to the immunogenic regions of the studied proteins are also detected in mice infected with some bacterial pathogens and in humans with bacterial meningitis. A region of IgA1 protease was identified that is not capable of producing antibodies during immunization of animals, but that detects homologous antibodies in the blood of humans and animals recovered from bacterial infections. It has been suggested that this fragment plays a regulatory role in the process of immunogenesis.

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Authors and Affiliations

  1. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

    O. V. Kotel’nikova, Yu. A. Prokopenko, A. A. Zinchenko, O. A. Razgulyaeva, E. A. Nokel’, D. M. Karlinsky, L. S. Zhigis & L. D. Rumsh

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  1. O. V. Kotel’nikova
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  2. Yu. A. Prokopenko
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  3. A. A. Zinchenko
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  4. O. A. Razgulyaeva
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  5. E. A. Nokel’
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  6. D. M. Karlinsky
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  7. L. S. Zhigis
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  8. L. D. Rumsh
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Corresponding author

Correspondence to L. S. Zhigis.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 173, No. 4, pp. 436-439, April, 2022

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Kotel’nikova, O.V., Prokopenko, Y.A., Zinchenko, A.A. et al. Specific Antibodies to the Fragments of Meningococcal IgA1 Protease during the Formation of Immunity to Bacterial Infections. Bull Exp Biol Med 173, 429–432 (2022). https://doi.org/10.1007/s10517-022-05580-6

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  • DOI: https://doi.org/10.1007/s10517-022-05580-6

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