The study included umbilical cord blood samples (n=64) intended for cryogenic storage of hematopoietic stem cells and obtained from patients with a history of mild and moderate forms of COVID-19 during pregnancy. The control group was composed of samples (n=746) obtained from healthy women in labor. A comparative analysis of the volume of cord blood collected, the total leukocyte count, the relative and absolute content of cells with the CD34+/CD45+ phenotype revealed no significant differences between the groups.
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Romanov YuA. SARS-CoV-2, COVID-19 and cardiovascular complications from the position of vascular endothelium. Kardiol. Vestn. 2022;17(1):21-28. Russian. doi: 10.17116/Cardiobulletin20221701121
Aghaamoo S, Ghods K, Rahmanian M. Pregnant women with COVID-19: the placental involvement and consequences. J. Mol. Histol. 2021;52(3):427-435. doi: https://doi.org/10.1007/s10735-021-09970-4
Agostinis C, Mangogna A, Balduit A, Aghamajidi A, Ricci G, Kishore U, Bulla R. COVID-19, pre-eclampsia, and complement system. Front. Immunol. 2021;12:775168. doi: https://doi.org/10.3389/fimmu.2021.775168
Barker JN, Kempenich J, Kurtzberg J, Brunstein CG, Delaney C, Milano F, Politikos I, Shpall EJ, Scaradavou A, Dehn J. CD34+ cell content of 126,341 cord blood units in the US inventory: implications for transplantation and banking. Blood Adv. 2019;3(8):1267-1271. doi: https://doi.org/10.1182/bloodadvances.2018029157
Conde-Agudelo A, Romero R. SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis. Am. J. Obstet. Gynecol. 2022;226(1):68-89.e3. doi: https://doi.org/10.1016/j.ajog.2021.07.009
Easterlin MC, Crimmins EM, Finch CE. Will prenatal exposure to SARS-CoV-2 define a birth cohort with accelerated aging in the century ahead? J. Dev. Orig. Health Dis. 2021;12(5):683-687. doi: https://doi.org/10.1017/S204017442000104X
Elsaddig M, Khalil A. Effects of the COVID pandemic on pregnancy outcomes. Best Pract. Res. Clin. Obstet. Gynaecol. 2021;73:125-136. doi: https://doi.org/10.1016/j.bpobgyn.2021.03.004
Fajgenbaum DC, June CH. Cytokine storm. N. Engl. J. Med. 2020;383(23):2255-2273. doi: https://doi.org/10.1056/NEJMra2026131
Finsterer J, Scorza FA, Scorza CA, Fiorini AC. Extrapulmonary onset manifestations of COVID-19.Clinics (Sao Paulo). 2021;76:e2900. doi: 10.6061/clinics/2021/e2900
Girardelli S, Mullins E, Lees CC. COVID-19 and pregnancy: Lessons from 2020. Early Hum. Dev. 2021;162:105460. doi: https://doi.org/10.1016/j.earlhumdev.2021.105460
Gratama JW, Orfao A, Barnett D, Brando B, Huber A, Janossy G, Johnsen HE, Keeney M, Marti GE, Preijers F, Rothe G, Serke S, Sutherland DR, Van der Schoot CE, Schmitz G, Papa S. Flow cytometric enumeration of CD34+ hematopoietic stem and progenitor cells. European Working Group on Clinical Cell Analysis. Cytometry. 1998;34(3):128-142. doi: 10.1002/(sici)1097-0320(19980615)34:3<128::aid-cyto3>3.0.co;2-d
Gumina DL, Black CP, Balasubramaniam V, Winn VD, Baker CD. Umbilical cord blood circulating progenitor cells and endothelial colony-forming cells are decreased in preeclampsia. Reprod. Sci. 2017;24(7):1088-1096. doi: https://doi.org/10.1177/1933719116678692
Gupta AO, Wagner JE. Umbilical cord blood transplants: current status and evolving therapies. Front. Pediatr. 2020;8:570282. doi: https://doi.org/10.3389/fped.2020.570282
Jaime-Pérez JC, Colunga-Pedraza JE, Monreal-Robles R, Colunga-Pedraza PR, Méndez-Ramírez N, Salazar-Riojas R, Gómez-Almaguer D. Acute maternal cytomegalovirus infection is associated with significantly decreased numbers of CD34+ cells in umbilical cord blood. Blood Cells Mol. Dis. 2012;49(3-4):166-169. doi: https://doi.org/10.1016/j.bcmd.2012.06.005
Kyle MH, Dumitriu D. The effect of coronavirus disease 2019 on newborns. Curr. Opin. Pediatr. 2021;33(6):618-624. doi: https://doi.org/10.1097/MOP.0000000000001063
Liotta EM, Batra A, Clark JR, Shlobin NA, Hoffman SC, Orban ZS, Koralnik IJ. Frequent neurologic manifestations and encephalopathy-associated morbidity in Covid-19 patients. Ann. Clin. Transl. Neurol. 2020;7(11):2221-2230. doi: https://doi.org/10.1002/acn3.51210
Munoz J, Shah N, Rezvani K, Hosing C, Bollard C.M, Oran B, Olson A, Popat U, Molldrem J, McNiece IK, Shpall EJ. Concise review: umbilical cord blood transplantation: past, present, and future. Stem Cells Transl. Med. 2014;3(12):1435-1443. doi: https://doi.org/10.5966/sctm.2014-0151
Naidu SAG, Clemens R.A, Pressman P, Zaigham M, Kadkhoda K, Davies KJA, Naidu AS. COVID-19 during pregnancy and postpartum. J. Diet Suppl. 2022;19(1):115-142. doi: https://doi.org/10.1080/19390211.2020.1834049
Nordin F, Idris MRM, Mahdy ZA, Wahid SFA. Preeclampsia in pregnancy affecting the stemness and differentiation potency of haematopoietic stem cell of the umbilical cord blood. BMC Pregnancy Childbirth. 2020;20(1):399. doi: https://doi.org/10.1186/s12884-020-03084-7
Podestà M, Bruschettini M, Cossu C, Sabatini F, Dagnino M, Romantsik O, Spaggiari GM, Ramenghi LA, Frassoni F. Preterm cord blood contains a higher proportion of immature hematopoietic progenitors compared to term samples. PLoS One. 2015;10(9):e0138680. doi: https://doi.org/10.1371/journal.pone.0138680
Pons S, Fodil S, Azoulay E, Zafrani L. The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection. Crit. Care. 2020;24(1):353. doi: https://doi.org/10.1186/s13054-020-03062-7
Roberts DJ, Bebell LM, Edlow AG. Severe acute respiratory syndrome coronavirus 2 ACE2 and TMPRSS2 receptor protein expression patterns throughout gestation. J. Infect. Dis. 2021;224(Suppl. 6):S642-S646. doi: https://doi.org/10.1093/infdis/jiab164
Romanov YA, Tarakanov OP, Radaev SM, Dugina TN, Ryaskina SS, Darevskaya AN, Morozova YV, Khachatryan WA, Lebedev KE, Zotova NS, Burkova AS, Sukhikh GT, Smirnov VN. Human allogeneic AB0/Rh-identical umbilical cord blood cells in the treatment of juvenile patients with cerebral palsy. Cytotherapy. 2015;17(7):969-978. doi: https://doi.org/10.1016/j.jcyt.2015.02.010
Rowisha MA, El-Shanshory MR, El-Hawary EE, Ahmed AY, Altoraky SRM. Impact of maternal and neonatal factors on umbilical cord CD34+ cells. Stem Cell Investig. 2020;7:5. doi: https://doi.org/10.21037/sci.2020.03.01
Salem D, Katranji F, Bakdash T. COVID-19 infection in pregnant women: Review of maternal and fetal outcomes. Int. J. Gynaecol. Obstet. 2021;152(3):291-298. doi: https://doi.org/10.1002/ijgo.13533
Sathiya R, Rajendran J, Sumathi S. COVID-19 and preeclampsia: overlapping features in pregnancy. Rambam Maimonides Med. J. 2022;13(1):e0007. doi: https://doi.org/10.5041/RMMJ.10464
Schwartz DA, Dhaliwal A. Coronavirus diseases in pregnant women, the placenta, fetus, and neonate. Adv. Exp. Med. Biol. 2021;1318:223-241. doi: https://doi.org/10.1007/978-3-030-63761-3_14
Shah MD, Sumeh AS, Sheraz M, Kavitha MS, Venmathi Maran BA, Rodrigues KF. A mini-review on the impact of COVID 19 on vital organs.Biomed. Pharmacother. 2021;143:112158. doi: https://doi.org/10.1016/j.biopha.2021.112158
Shchegolev AI, Kulikova GV, Tumanova UN, Shmakov RG, Sukhikh GT. Morphometric parameters of placental villi in parturient women with COVID-19. Bull. Exp. Biol. Med. 2021;172(1):85-89. doi: https://doi.org/10.1007/s10517-021-05337-7
Shields LE, Andrews RG. Gestational age changes in circulating CD34+ hematopoietic stem/progenitor cells in fetal cord blood. Am. J. Obstet. Gynecol. 1998;178(5):931-937. doi: https://doi.org/10.1016/s0002-9378(98)70526-5
Shmakov RG, Prikhodko A, Polushkina E, Shmakova E, Pyregov A, Bychenko V, Priputnevich TV, Dolgushin GO, Yarotskaya E, Pekarev O, Bolibok N, Degtyarev D, Sukhikh GT. Clinical course of novel COVID-19 infection in pregnant women. J. Matern. Fetal Neonatal Med. 2020:1-7. doi: https://doi.org/10.1080/14767058.2020.1850683
Singh S, Pandey R, Tomar S, Varshney R, Sharma D, Gangenahalli G. A brief molecular insight of COVID-19: epidemiology, clinical manifestation, molecular mechanism, cellular tropism and immuno-pathogenesis. Mol. Cell. Biochem. 2021;476(11):3987-4002. doi: https://doi.org/10.1007/s11010-021-04217-y
Smadja DM, Mentzer SJ, Fontenay M, Laffan MA, Ackermann M, Helms J, Jonigk D, Chocron R, Pier GB, Gendron N, Pons S, Diehl JL, Margadant C, Guerin C, Huijbers EJM, Philippe A, Chapuis N, Nowak-Sliwinska P, Karagiannidis C, Sanchez O, Kümpers P, Skurnik D, Randi AM, Griffioen AW. COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects. Angiogenesis. 2021;24(4):755-788. doi: https://doi.org/10.1007/s10456-021-09805-6
Surbek DV, Danzer E, Steinmann C, Tichelli A, Wodnar-Filipowicz A, Hahn S, Holzgreve W. Effect of preeclampsia on umbilical cord blood hematopoietic progenitor-stem cells. Am. J. Obstet. Gynecol. 2001;185(3):725-729. doi: https://doi.org/10.1067/mob.2001.117343
Wu Z, Zhang Q, Ye G, Zhang H, Heng BC, Fei Y, Zhao B, Zhou J. Structural and physiological changes of the human body upon SARS-CoV-2 infection. J. Zhejiang Univ. Sci. B. 2021;22(4):310-317. doi: https://doi.org/10.1631/jzus.B2000523
Wynn LA, Madrigal A. Predictive analytics and cord blood banking: toward utilization-based unit selection. Cytotherapy. 2021;23(7):641-646. doi: https://doi.org/10.1016/j.jcyt.2021.01.002
Yi ES, Lee JW, Kim YJ, Sung KW, Koo HH, Yoo KH. Risk factors and outcomes of cytomegalovirus infection in children post cord blood transplantation with focus on impact of graft-versus-host disease and immunosuppressants. Ann. Hematol. 2022;101(2):409-419. doi: https://doi.org/10.1007/s00277-021-04707-5
Ziganshina MM, Yarotskaya EL, Bovin NV, Pavlovich SV, Sukhikh GT. Can endothelial glycocalyx be a major morphological substrate in pre-eclampsia? Int. J. Mol. Sci. 2020;21(9):3048. doi: https://doi.org/10.3390/ijms21093048
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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 78-83, June, 2022
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Romanov, Y.A., Kosolapova, Y.A., Zubkov, V.V. et al. Mild or Moderate COVID-19 during Pregnancy Does Not Affect the Content of CD34+ Hematopoietic Stem Cells in Umbilical Cord Blood of Newborns. Bull Exp Biol Med 173, 523–528 (2022). https://doi.org/10.1007/s10517-022-05575-3
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DOI: https://doi.org/10.1007/s10517-022-05575-3