Unsymmetrical dimethylhydrazine (UDMH, heptyl) and its derivatives are used in the rocket and space industry as components of rocket fuel. UDMH is a highly toxic compound exhibiting irritant, hepatotoxic, and neurotoxic properties. In this study, the toxic effect of heptyl on isolated rat heart and lymphatic vessels was demonstrated. Acute exposure to UDMH leads to vasoconstriction of the coronary vessels of the isolated heart and pronounced stimulation of isolated lymphangions starting from the concentration of 10-4 M. The changes are dose-dependent. After exposure to UDMH in high concentrations (10-2 M), the changes in the functional parameters became irreversible. The obtained results provide evidence for the organ-specific effect of UDMH on visceral muscle organs.
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Avakyan AKh. New molecular criteria for evaluating the toxic effect of hydrazine derivatives. Reactive oxygen species as key agents in the toxicity mechanism. Farmakol. Toksikol. 1990;53(1):70-73. Russian.
Belov AA. On the toxicity and hazard of hydrazine and its derivatives. Sovremen. Probl. Toksikol. 2000;(1):25-32. Russian.
Kutsenko SA, Butomo NV, Grebenyuk AN. Military Toxicology, Radiobiology, and Medical Protection. St. Petersburg, 2004. Russian.
Lavrinenko IA, Lavrinenko VA. 1,1-Dimethylhydrazine: mutagenic and general toxic properties. Vestn. Novosib. Gos. Univer. Ser.: Biol., Klin. Med. 2012;10(3):229-236. Russian.
Lomakin AI, Trikman OP, Skripkina LE, Dorokhova OP, Yushkova NG, Blokhin VP, Krupichev YuL, Nikitina GI. Toxic effects of unsymmetric dimethylhydrazine (heptyl) on the human body. Vestn. Klin. Bol. No. 51. 2011;5(1-3):59-61. Russian.
Yaguzhinskii LS, Manukhov IV, Vagapova ER, Kessenikh AG, Konopleva MN, Zavil’gek’skii GB, Kotova VYu, Bruskov VI, Maslennikov AA, Smirnova EG, Chalkin SF. Experimental Studies of the Effect of Low Concentrations of Heptyl and Its Hydrolysis Products on Water and Biological Objects. Moscow, 2015. Russian.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 9, pp. 283-286, September, 2021
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Nechaykina, O.V., Laptev, D.S., Petunov, S.G. et al. Effect of Unsymmetrical Dimethylhydrazine on Isolated Heart and Lymphatic Vessels. Bull Exp Biol Med 172, 297–300 (2022). https://doi.org/10.1007/s10517-022-05380-y
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DOI: https://doi.org/10.1007/s10517-022-05380-y