We studied the effects of novel sterically hindered phenol, 4-methyl-2,6-diisobornyl phenol (dibornol) on the rheological properties of the blood in the model of myocardial ischemia/reperfusion. Dibornol (100 mg/kg intraperitoneally for 3 days before and 5 days after ischemia/reperfusion) decreased blood viscosity by 9-25% in comparison with that in sham-operatedanimals by modulating cellular (erythrocyte deformability and aggregation) and plasma (plasma viscosity) rheological parameters. Normalization of blood rheology under the influence of dibornol increased the availability of oxygen to tissues at high shear rates by 9-18% after acute ischemia/reperfusion in rats.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
V. V. Gaivoronskaya and S. V. Okovityi, Obzory Klin. Farmakol. Lek. Ter., 2, No. 4, 45-70 (2003).
A. Kh. Kogan, Patol. Fiziol. Eksper. Ter., No. 3, 79-81 (1979).
E. B. Men’shchikova, V. Z. Lankin, N. K. Zenkov, et al., Oxidative stress. Prooxidants and Antioxidants [in Russian], Moscow (2006).
M. B. Plotnikov, O. I. Aliev, and F. V. Popel, Klin. Lab. Diagnost., No. 3, 457-458 (1995).
M. B. Plotnikov, V. I. Smolyakova, I. S. Ivanov, et al., Bull. Exp. Biol. Med., 145, No. 3, 328-330 (2008).
M. B. Plotnikov, V. I. Smolyakova, I. S. Ivanov, et al., Bull. Exp. Biol. Med., 149, No. 6, 721-723 (2010).
M. B. Plotnikov, N. A. Tyukavkina, and T. M. Plotnikova, Medicinal Preparations Based on Diquertin [in Russian], Tomsk (2005).
V. V. Fomin and S. V. Moiseev, Klinizist, No. 1, 46-52 (2007).
M. Bessis, N. Mohandas, and S. Feo, Blood Cells, 6, No. 3, 315-327 (1980).
S. Chien, Bibl. Anat., 16, Pt. 2, 472-474 (1977).
W. Koenig, M. Sund, B. Filipiak, et al., Arterioscler. Thromb. Vasc. Biol., 18, No. 5, 768-772 (1998).
P. W. Kleikers, K. Wingler, J. J. Hermans, et al., J. Mol. Med. (Berl)., 90, No. 12, 1391-1406 (2012).
F. Larcan and J. F. Stoltz, J. Mal. Vasc., 14, No. 3, 240-253 (1989).
J. F. Stoltz and M. Donner, Schweiz. Med. Wochenschr. Suppl., 43, 41-49 (1991).
M. G. Tozzi-Ciancarrelli, C. Di Massino, A. Masciou, et al., Cardioscience, 4, No. 4, 231-234 (1993).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 2, pp. 173-176, February, 2014
Rights and permissions
About this article
Cite this article
Plotnikova, T.M., Chernysheva, G.A., Smol’yakova, V.I. et al. Hemorheologic Effects of Dibornol in a Model of Myocardial Ischemia/Reperfusion. Bull Exp Biol Med 157, 211–214 (2014). https://doi.org/10.1007/s10517-014-2527-8
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-014-2527-8