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Putative Role of Ligands of DNIC in the Physiological Action of the Complex

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In a relatively isolated system of avian embryo, the metabolism of NO, a component of the dinitrosyl iron complexes (DNIC), the main NO donor in most tissues, depends on the ligands that make up the complex. This fact corroborates the earlier hypothesis that these ligands perform a regulatory function in NO metabolism. It is also shown that nitrite injected into the embryo is not oxidized to nitrate like NO in DNIC, but is accumulated outside the amniotic sac. Normally, nitrite is present in an embryo in trace amounts. These facts suggest that NO in the embryo is transferred from the donor molecule to a target in the embryo tissues further transformed with minimum oxidation to nitrite.

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Authors and Affiliations

  1. All-Russian Research and Technological Institute of Poultry, Russian Academy of Sciences, Sergiev Posad, Moscow region, Russia

    V. Yu. Titov & A. M. Dolgorukova

  2. N. I. Pirogov Russian National Research Medical University, Ministry of the Health of the Russian Federation, Moscow, Russia

    V. Yu. Titov & A. N. Osipov

  3. K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, Moscow, Russia

    V. Yu. Titov & I. I. Kochish

Authors
  1. V. Yu. Titov
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  2. A. M. Dolgorukova
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  3. A. N. Osipov
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  4. I. I. Kochish
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Correspondence to V. Yu. Titov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 5, pp. 577-582, May, 2021

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Titov, V.Y., Dolgorukova, A.M., Osipov, A.N. et al. Putative Role of Ligands of DNIC in the Physiological Action of the Complex. Bull Exp Biol Med 171, 606–610 (2021). https://doi.org/10.1007/s10517-021-05278-1

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  • DOI: https://doi.org/10.1007/s10517-021-05278-1

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