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Can Summary Nitrite+Nitrate Content Serve as an Indicator of NO Synthesis Intensity in Body Tissues?

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Bulletin of Experimental Biology and Medicine Aims and scope

Studies with the use of a highly specific enzymatic sensor demonstrated that, contrary to the common opinion, normally nitrate is in fact not present in the most important physiological fluids. NO metabolites in the amniotic fluid and semen are mainly presented by NO donor compounds. Therefore, the intensity of NO synthesis can be evaluated by the total content of all its metabolites, but not by the widely used summary nitrite+nitrate content.

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References

  1. V. Yu. Titov, Yu. M. Petrenko, A. F. Vanin, and I. I. Stepuro, Biofizika, 55, 95-106 (2010).

    PubMed  CAS  Google Scholar 

  2. V. Yu. Titov, Yu. M. Petrenko, and A. F. Vanin, Klin. Lab. Diagnost., No. 9, 6–14 (2009).

  3. N. Benjamin and P. Vallance, Lancet, 344, 960 (1994).

    Article  PubMed  CAS  Google Scholar 

  4. J. W. Blum, H. Dosogne, D. Hoeben, et al., Domest. Anim. Endocrinol., 19, No. 2, 223–235 (2000).

    Article  PubMed  CAS  Google Scholar 

  5. J. W. Blum, C. Morel, H. M. Hammon, et al., Comp. Biochem. Physiol. A Mol. Integr. Physiol., 130, No. 2, 271–282 (2001).

    Article  PubMed  CAS  Google Scholar 

  6. B. Gaston, Biochim. Biophys. Acta, 1411, Nos. 2–3, 323–333 (1999).

    PubMed  CAS  Google Scholar 

  7. M. T. Gladwin, J. H. Shelhamer, A. Schechter, et al., Proc. Natl. Acad. Sci. USA, 97, No. 21, 11 482–11 487 (2000).

    Article  CAS  Google Scholar 

  8. D. Jang and G. A. Murrell, Free Radic. Biol. Med., 24, No. 9, 1511–1519 (1998).

    Article  PubMed  CAS  Google Scholar 

  9. H. Preik-Steinhoff and M. Kelm, J. Chromatogr. Biomed. Appl., 685, No. 2, 348–352 (1996).

    Article  CAS  Google Scholar 

  10. M. Retsky, A. Shakhov, G. Bliznetzova, et al., Russ. Agric. Sci., 30, 58–60 (2004).

    Google Scholar 

  11. P. Rhodes, A. M. Leone, P. L. Francis, et al., Biochem. Biophys. Res. Commun., 209, No. 2, 590–596 (1995).

    Article  PubMed  CAS  Google Scholar 

  12. I. S. Severina, O. G. Bussygina, N. V. Pyatakova, et al., Nitric Oxide, 8, No. 3, 155–163 (2003).

    Article  PubMed  CAS  Google Scholar 

  13. D. Tsikas, Anal. Chem., 72, No. 17, 4064–4072 (2000).

    Article  PubMed  CAS  Google Scholar 

  14. A. F. Vanin, A. Huisman, and E. E. Van Faassen, Methods Enzymol., 359, 27–42 (2002).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. N. I. Pirogov Russian National Research Medical University, Moscow, Russia

    V. Yu. Titov, A. V. Ivanova, V. A. Petrov & A. N. Osipov

  2. N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

    V. A. Serezhenkov, V. D. Mikoyan & A. F. Vanin

Authors
  1. V. Yu. Titov
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  2. A. V. Ivanova
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  3. V. A. Petrov
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  4. V. A. Serezhenkov
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  5. V. D. Mikoyan
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  6. A. F. Vanin
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  7. A. N. Osipov
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Correspondence to V. Yu. Titov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 6, pp. 816–819, June, 2012

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Titov, V.Y., Ivanova, A.V., Petrov, V.A. et al. Can Summary Nitrite+Nitrate Content Serve as an Indicator of NO Synthesis Intensity in Body Tissues?. Bull Exp Biol Med 153, 840–843 (2012). https://doi.org/10.1007/s10517-012-1839-9

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  • DOI: https://doi.org/10.1007/s10517-012-1839-9

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