We performed comparative analysis of 8-hydroxy-2’-deoxyguanosine in women in different climax stages with and without insomnia. The study involved 90 women aged 45 to 60 years divided into perimenopausal (n=30) and postmenopausal (n=60) groups. After questioning using special sleep questionnaires (Insomnia Severity Index, Epworth Sleepiness Scale, Munich Chronotype Questionnaire), the groups were divided into subgroups with insomnia and without it (control). 8-Hydroxy-2’-deoxyguanosine was assayed in blood serum by ELISA. The higher levels of 8-hydroxy-2’-deoxyguanosine in postmenopausal women with insomnia in comparison with the control and perimenopausal patients (p<0.05) attested to oxidative DNA damage in this cohort of patients.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 3, pp. 369-372, March, 2021
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Semenova, N.V., Madaeva, I.M., Brichagina, A.S. et al. 8-Hydroxy-2’-Deoxyguanosine as an Oxidative Stress Marker in Insomnia. Bull Exp Biol Med 171, 384–387 (2021). https://doi.org/10.1007/s10517-021-05233-0
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DOI: https://doi.org/10.1007/s10517-021-05233-0