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Evaluation of the Association of rs4680 COMT Polymorphism and Clinical Parameters of the Tumor in Colorectal Cancer (a Pilot Study)

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We analyzed association of rs4680 polymorphism of catechol-O-methyltransferase (COMT) gene with clinical parameters of the tumor in patients with colorectal cancer (n=100). Based on the classification of the tumor according to the TNM system, groups were formed taking into account the size and spreading of the primary tumor (T1+T2 vs Т3+Т4) and the presence of regional (N0 vs N1) and distant metastases (M0 vs M1). An association of the AA genotype with an almost 7-fold increased capacity for invasive tumor growth was found (p<0.05; according to recessive (AA vs GG+GA) and codominant (AA vs GG) inheritance models). A positive relationship of minor allele A with increased malignancy of tumor cells was revealed at the trend level. No significant associations with either regional or distant metastasis were found.

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Authors and Affiliations

  1. A. F. Tsyb Medical Radiological Research Center — Affiliated Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Obninsk, Russia

    T. I. Ivanova, A. L. Potapov, D. V. Zemskova, V. A. Khorokhorina, P. V. Shegai, S. A. Ivanov & A. D. Kaprin

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  1. T. I. Ivanova
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  2. A. L. Potapov
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  3. D. V. Zemskova
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  4. V. A. Khorokhorina
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  5. P. V. Shegai
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  6. S. A. Ivanov
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  7. A. D. Kaprin
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Corresponding author

Correspondence to T. I. Ivanova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 8, pp. 231-235, August, 2020

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Ivanova, T.I., Potapov, A.L., Zemskova, D.V. et al. Evaluation of the Association of rs4680 COMT Polymorphism and Clinical Parameters of the Tumor in Colorectal Cancer (a Pilot Study). Bull Exp Biol Med 170, 254–257 (2020). https://doi.org/10.1007/s10517-020-05046-7

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  • DOI: https://doi.org/10.1007/s10517-020-05046-7

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