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Hypercapnia and Hypoxia Stimulate Proliferation of Astrocytes and Neurons In Vitro

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We compared proliferative activity and hypoxic tolerance in a co-culture of neurons and astrocytes in vitro after preliminary exposure to normobaric hypoxia and/or permissive hypercapnia in vivo. Preliminary hypoxic exposure increased the cell index throughout the 72-h period of observation, the effect of hypercapnia was observed on days 1 and 3 of the experiment, and the effect of hypercapnic hypoxia was noted only on day 1. Preliminary hypoxic exposure has a protective effect on nerve cells under conditions of chemical hypoxia. This suggests that hypercapnia and hypoxia activate proliferative activity of nerve cells, which can be viewed as a mechanism of their neuroprotective effectiveness.

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Authors and Affiliations

  1. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia

    P. P. Tregub, A. V. Morgun, E. D. Osipova, N. A. Malinovskaya & D. A. Kuzovkov

  2. Altai Medical Institute of Postgraduate Education, Barnaul, Russia

    P. P. Tregub & V. P. Kulikov

Authors
  1. P. P. Tregub
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  2. A. V. Morgun
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  3. E. D. Osipova
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  4. V. P. Kulikov
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  5. N. A. Malinovskaya
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  6. D. A. Kuzovkov
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Corresponding author

Correspondence to P. P. Tregub.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 6, pp. 695-699, June, 2020

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Tregub, P.P., Morgun, A.V., Osipova, E.D. et al. Hypercapnia and Hypoxia Stimulate Proliferation of Astrocytes and Neurons In Vitro. Bull Exp Biol Med 169, 755–758 (2020). https://doi.org/10.1007/s10517-020-04972-w

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  • DOI: https://doi.org/10.1007/s10517-020-04972-w

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