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Brain Changes in the White Matter of the Brain White Matter Changes and Cognitive Functions in Asymptomatic Patients

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We analyzed the relationship between white matter hyperintensities in T2-weighted MR-images (according to Fazekas score) and the state of cognitive functions (total MOCA score) in 65 asymptomatic individuals. A relationship between the presence/number of lesions in the deep white matter of the brain and cognitive status according to the total MOCA score was revealed. The results of cognitive functions assessment also correlated with MRI evaluation of the severity of brain cortex atrophy. The severity of deep white matter lesions according to the Fazekas scale were also associated with end-diastolic blood flow velocities in the middle cerebral, vertebral, and basilar arteries.

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Authors and Affiliations

  1. Federal Center for Cerebrovascular Pathology and Stroke, Ministry of Health of the Russian Federation, Moscow, Russia

    A. B. Berdalin, A. K. Nikogosova, I. L. Gubskiy, E. A. Kovrazhkina, L. V. Gubskiy & V. G. Lelyuk

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  1. A. B. Berdalin
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  2. A. K. Nikogosova
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  3. I. L. Gubskiy
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  4. E. A. Kovrazhkina
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  5. L. V. Gubskiy
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  6. V. G. Lelyuk
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Correspondence to A. B. Berdalin.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 5, pp. 559-563, May, 2020

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Berdalin, A.B., Nikogosova, A.K., Gubskiy, I.L. et al. Brain Changes in the White Matter of the Brain White Matter Changes and Cognitive Functions in Asymptomatic Patients. Bull Exp Biol Med 169, 630–634 (2020). https://doi.org/10.1007/s10517-020-04942-2

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  • DOI: https://doi.org/10.1007/s10517-020-04942-2

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