A new model of cirrhosis of the liver was created in experiment on 30 rats. Over 3 weeks, experimental animals in addition to the standard diet daily intragastrically received corn oil in combination with intragastric administration of acetaminophen in a dose of 500 mg/day. High-fat load in combination with acetaminophen over 3 weeks led to the development of focal biliary cirrhosis.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 3, pp. 391-396, March, 2020
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Tropskaya, N.S., Kislyakova, E.A., Vilkova, I.G. et al. Experimental Model of Cirrhosis of the Liver. Bull Exp Biol Med 169, 416–420 (2020). https://doi.org/10.1007/s10517-020-04899-2
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DOI: https://doi.org/10.1007/s10517-020-04899-2