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Effect of Vanadium Complex with Enzymatic Hydrolysate of Soy Protein on Carbohydrate and Lipid Metabolism Disorders in Male Wistar Rats

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The effects of vanadium complex with enzymatic hydrolysate of soy protein (V-EHSPI) were studied in male Wistar rats with induced disorders of carbohydrate and lipid metabolism. The content of vanadium (IV) in the studied complex was 15.8 mg/g dry product. High-lipid high-carbohydrate diet was used to induce disorders of lipid and carbohydrate metabolism. Addition of vanadium in three different doses to the diet over 100-day experiment reduced body weight gain and the levels of glucose, insulin, leptin, and triglycerides. V-EHSPI produced beneficial effects on carbohydrate and lipid metabolism even in a dose 5 μg/kg body weight/day (calculated from the mean food consumption over the entire treatment period). Significant inhibition of growth and changes in the weight of organs in animals treated with V-EHSPI attested to toxicity of vanadium in the studied dose range.

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References

  1. Zorin SN, Sidorova YuS, Lobanova YuN, Mazo VK. Organic source of vanadium. preparation and physicalchemical characteristic. Vopr. Pit. 2019;88(1):85-90. Russian.

  2. Sidorova YuS, Shipelin VA, Petrov NA, Frolova YuV, Kochetkova AA, Mazo VK. The experimental evaluation in vivo of hypoglycemic properties of functional food ingredient – polyphenolic food matrix. Vopr. Pit. 2018;87(4):5-13. Russian.

  3. Cam MC, Brownsey RW, McNeill JH. Mechanisms of vanadium action: insulin-mimetic or insulin-enhancing agent? Can. J. Physiol. Pharmacol. 2000;78(10):829-847.

    Article  CAS  Google Scholar 

  4. Crans DC. Chemistry and insulin-like properties of vanadium(IV) and vanadium(V) compounds. J. Inorg. Biochem. 2000;80(1-2):123-131.

    Article  CAS  Google Scholar 

  5. Gross B, Pawlak M, Lefebvre P, Staels B. PPARs in obesityinduced T2DM, dyslipidaemia and NAFLD. Nat. Rev. Endocrinol. 2017;13(1):36-49.

    Article  CAS  Google Scholar 

  6. Jiang P, Dong Z, Ma B, Ni Z, Duan H, Li X, Wang B, Ma X, Wei Q, Ji X, Li M. Effect of Vanadyl Rosiglitazone, a New Insulin-Mimetic Vanadium Complexes, on Glucose Homeostasis of Diabetic Mice. Appl. Biochem. Biotechnol. 2016;180(5):841-851.

    Article  CAS  Google Scholar 

  7. Mohammad A, Sharma V, McNeill JH. Vanadium increases GLUT4 in diabetic rat skeletal muscle. Mol. Cell. Biochem. 2002;233(1-2):139-143.

    Article  CAS  Google Scholar 

  8. Niu X, Xiao R, Wang N, Wang Z, Zhang Y, Xia Q, Yang X. The Molecular Mechanisms and Rational Design of Anti-Diabetic Vanadium Compounds. Curr. Top. Med. Chem. 2016;16(8):811-822.

    Article  CAS  Google Scholar 

  9. Sun Q, Sekar N, Goldwaser I, Gershonov E, Fridkin M, Shechter Y. Vanadate restores glucose 6-phosphate in diabetic rats: a mechanism to enhance glucose metabolism. Am. J. Physiol. Endocrinol. Metab. 2000;279(2):E403-E410.

    Article  CAS  Google Scholar 

  10. Thompson KH, Lichter J, LeBel C, Scaife MC, McNeill JH, Orvig C. Vanadium treatment of type 2 diabetes: a view to the future. J. Inorg. Biochem. 2009;103(4):554-558.

    Article  CAS  Google Scholar 

  11. Tsave O, Yavropoulou MP, Kafantari M, Gabriel C, Yovos JG, Salifoglou A. Comparative assessment of metal-specific adipogenic activity in zinc and vanadium-citrates through associated gene expression. J. Inorg. Biochem. 2018;186:217-227.

    Article  CAS  Google Scholar 

  12. Wang YX, Chen HG, Li XD, Chen YJ, Liu C, Feng W, Zeng Q, Wang P, Pan A, Lu WQ. Concentrations of vanadium in urine and seminal plasma in relation to semen quality parameters, spermatozoa DNA damage and serum hormone levels. Sci. Total Environ. 2018;645:441-448.

    Article  CAS  Google Scholar 

  13. Xie M, Chen D, Zhang F, Willsky GR, Crans DC, Ding W. Effects of vanadium (III, IV, V)-chlorodipicolinate on glycolysis and antioxidant status in the liver of STZ-induced diabetic rats. J. Inorg. Biochem. 2014;136:47-56.

    Article  CAS  Google Scholar 

  14. Yoshikawa Y, Sakurai H, Crans DC, Micera G, Garribba E. Structural and redox requirements for the action of anti-diabetic vanadium compounds. Dalton Trans. 2014;43(19):6965-6972.

    Article  CAS  Google Scholar 

  15. Zhao P, Yang X. Vanadium compounds modulate PPARγ activity primarily by increasing PPARγ protein levels in mouse insulinoma NIT-1 cells. Metallomics. 2013;5(7):836-843.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Federal Research Centre of Nutrition and Biotechnology, Moscow, Russia

    Yu. S. Sidorova, S. N. Zorin, N. A. Petrov, A. A. Shumakova, Yu. V. Frolova & V. K. Mazo

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  1. Yu. S. Sidorova
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  2. S. N. Zorin
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  3. N. A. Petrov
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  4. A. A. Shumakova
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  5. Yu. V. Frolova
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  6. V. K. Mazo
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Corresponding author

Correspondence to Yu. S. Sidorova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 11, pp. 577-581, November, 2019

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Sidorova, Y.S., Zorin, S.N., Petrov, N.A. et al. Effect of Vanadium Complex with Enzymatic Hydrolysate of Soy Protein on Carbohydrate and Lipid Metabolism Disorders in Male Wistar Rats. Bull Exp Biol Med 168, 637–640 (2020). https://doi.org/10.1007/s10517-020-04769-x

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  • DOI: https://doi.org/10.1007/s10517-020-04769-x

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