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Remodeling of the Extracellular Matrix of the Liver in Mice with BCG-Induced Granulomatosis after Administration of Liposome-Encapsulated Composition of Oxidized Dextran and Isonicotinic Acid Hydrazide

  • IMMUNOLOGY AND MICROBIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Remodeling of the extracellular matrix of the liver in mice with BCG-induced granulomatosis after 2-month course of intraperitoneal injections of isonicotinic acid hydrazide, oxidized dextran conjugated with isonicotinic acid hydrazide, dextrazide, and its liposome-encapsulated form manifested in modification of the proteoglycan composition and hydroxyproline fractions associated with changes in hyaluronidase and MMP activities. The antifibrotic effect of dextrazide and its liposome-encapsulated form manifested in reduction of hydroxyproline fractions that reflected the process of collagen synthesis. Administration of isonicotinic acid hydrazide was followed by a decrease in hydroxyproline fractions reflecting collagen synthesis (antifibrotics effect) and degradation (profibrotic effect), which can be explained by its hepatotoxic activity.

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Authors and Affiliations

  1. Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia

    L. B. Kim, A. N. Putyatina, G. S. Russkikh & V. A. Shkurupy

  2. Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia

    V. A. Shkurupy

Authors
  1. L. B. Kim
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  2. A. N. Putyatina
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  3. G. S. Russkikh
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  4. V. A. Shkurupy
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Correspondence to L. B. Kim.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 8, pp. 209-214, August, 2019

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Kim, L.B., Putyatina, A.N., Russkikh, G.S. et al. Remodeling of the Extracellular Matrix of the Liver in Mice with BCG-Induced Granulomatosis after Administration of Liposome-Encapsulated Composition of Oxidized Dextran and Isonicotinic Acid Hydrazide. Bull Exp Biol Med 168, 254–258 (2019). https://doi.org/10.1007/s10517-019-04686-8

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  • DOI: https://doi.org/10.1007/s10517-019-04686-8

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