The liposomal form of isonicotinic acid hydrazide conjugate with oxidized dextran (liposomeencapsulated dextrazide, LEDZ) injected intraperitoneally for 3 months to BALB/c mice with chronic BCG-induced granulomatosis (6 month after infection) down-regulated activities of protease (MMP) and antiprotease (TIMP-1, TIMP-2, α2-macroglobulin) components of the regulation system, which indicates a drop of destructive and inflammatory potential of BCGinduced granulomatosis. The persistent enhanced hyaluronidase activity in the liver and its reduced (normalized to control level) activity in the lungs after administration of LEDZ indicates a greater hydrolysis of hyaluronan in the liver than in the lungs. LEDZ-induced changes in MMP/TIMP system in mouse liver and lungs are characterized with relative elevation of protease activity over that of antiprotease one.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Global Tuberculosis Report 2018. WHO, 2019. [URL: https://www.who.int/tb/publications/global_report/gtbr2018_executive_summary_ru.pdf].
Kim LB, Putyatina AN, Russkikh GS, Shkurupy VA. Remodeling of the Extracellular Matrix of the Liver in Mice with BCGInduced Granulomatosis after Administration of Liposome-Encapsulated Composition of Oxidized Dextran and Isonicotinic Acid Hydrazide. Bull. Exp. Biol. Med. 2019;168(2):254-258. https://doi.org/10.1007/s10517-019-04686-8
Kim LB, Putyatina AN, Russkikh GS, Shkurupy VA. Effect of Liposomal Delivery of Oxidized Dextran with Isonicotinic Acid Hydrazide on Component Profile of Pulmonary Extracellular Matrix in Mice with BCG-Induced Granulomatosis.Bull. Exp. Biol. Med. 2019;168(2):259-263. https://doi.org/10.1007/s10517-019-04687-7.
Kim LB, Putyatina AN, Russkikh GS, Shkurupy VA. Antifibrotics Effect of Liposome-Encapsulated Composition of Oxidized Dextran and Isonicotinic Acid Hydrazide in Mice with BCG-Induced Granulomatosis Depends on Administration Route. Bull. Exp. Biol. Med. 2020;169(1):71-76. https://doi.org/10.1007/s10517-020-04827-4
Shkurupiy VA, Kim LB, Potapova OV, Cherdantseva LA, Putyatina AN, Nikonova IK. Fibrogenesis in granulomas and lung interstitium in tuberculous inflammation in mice. Bull. Exp. Biol. Med. 2014;156(6):731-5. https://doi.org/10.1007/s10517-014-2435-y.
Esmedlyaeva DS, Alexeyeva NP, Sapozhnikova NV, Dyakova ME, Perova TL, Kiryukhina LD, Zhuravlev VY. The system of matrix metalloproteinases and their role in patients with pulmonary tuberculosis. Biomed. Khimiya. 2016;62(5):593-598. Russian.
Esmedlyaeva DS, Alexeyeva NP, Gavrilov PV, Pavlova MV, D’yakova ME, Sokolovich EG. The system of matrix metalloproteinases and their role in patients with pulmonary tuberculosis. Tub. Bol. Legkikh. 2018;96(9):38-44. Russian.
Yarovaya GA, Dotsenko VL, Pashintseva LP, Nartikova VF, Paskhina TS. Determination of the activity of α1-antitrypsin and α2-macroglobulin in human blood plasma using a unified enzymatic method. Methods in Clinical Biochemistry. Orekhovich VN, ed. Moscow, 1982. P. 22-26. Russian.
Chen X, Kong X, Zhang Z, Chen W, Chen J, Li H, Cao W, Ge Y, Fang S. Alpha-2-macroglobulin as a radioprotective agent: a review. Chin. J. Cancer Res. 2014;26(5):611-621. https://doi.org/10.3978/j.issn.1000-9604.2014.09.04
Cui N, Hu M, Khalil RA. Biochemical and Biological Attributes of Matrix Metalloproteinases. Prog. Mol. Biol. Transl. Sci. 2017;147:1-73. https://doi.org/10.1016/bs.pmbts.2017.02.005
Elkington PT, Ugarte-Gil CA, Friedland JS. Matrix metalloproteinases in tuberculosis. Eur. Respir. J. 2011;38(2):456-464. https://doi.org/10.1183/09031936.00015411
Giannandrea M, Parks WC. Diverse functions of matrix metalloproteinases during fibrosis. Dis. Model Mech. 2014;7(2):193-203. https://doi.org/10.1242/dmm.012062
Kübler A, Luna B, Larsson C, Ammerman NC, Andrade BB, Orandle M, Bock KW, Xu Z, Bagci U, Mollura DJ, Marshall J, Burns J, Winglee K, Ahidjo BA, Cheung LS, Klunk M, Jain SK, Kumar NP, Babu S, Sher A, Friedland JS, Elkington PT, Bishai WR. Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation. J. Pathol. 2015;235(3):431-444. https://doi.org/10.1002/path.4432
Singh S, Kubler A, Singh UK, Singh A, Gardiner H, Prasad R, Elkington PT, Friedland JS. Antimycobacterial drugs modulate immunopathogenic matrix metalloproteinases in a cellular model of pulmonary tuberculosis. Antimicrob. Agents Chemother. 2014;58(8):4657-4665. https://doi.org/10.1128/AAC.02141-13
Ugarte-Gil CA, Elkington P, Gilman RH, Coronel J, Tezera LB, Bernabe-Ortiz A, Gotuzzo E, Friedland JS, Moore DA. Induced sputum MMP-1, -3 & -8 concentrations during treatment of tuberculosis. PLoS One. 2013;8(4):e61333. https://doi.org/10.1371/journal.pone.0061333
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 11, pp. 602-607, November, 2020
Rights and permissions
About this article
Cite this article
Kim, L.B., Putyatina, A.N., Russkikh, G.S. et al. Effect of Liposome-Encapsulated Dextrazide on Local Regulation of Extracellular Matrix Metabolism in Liver and Lungs of Mice with during Chronic BCG-Induced Granulomatosis. Bull Exp Biol Med 170, 640–644 (2021). https://doi.org/10.1007/s10517-021-05123-5
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-021-05123-5