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Morphological Assessment of Prostatotropic Activity of (3,5-Dimethyl-4-Hydroxy)Benzyl Thiododecane on a Model of Benign Prostatic Hyperplasia in Rats

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Prostatotropic activity of (3,5-dimethyl-4-hydroxy)benzyl thiododecane (T-DD) was evaluated on a model of benign prostatic hyperplasia induced in Wistar rats by chronic (2 months) intraperitoneal administration of sulpiride (40 mg/kg). Morphometric analysis of the dorsolateral lobe of the prostate showed that after the 2-month course of intragastric T-DD (100 mg/kg) administered in parallel with sulpiride, the volume density of glandular epithelium decreased by 1.7 times, while the volume density of prostate stroma increased by 2 times. After administration of the reference drug Permixon at a dose of 50 mg/kg, the volume densities of epithelium decreased by 1.3 times and stromal volume density increased by 1.5 times. The observed effects are presumably related to suppression of 5α-reductase activity and modulation of estrogen receptors in the prostate.

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Authors and Affiliations

  1. N. N. Vorozhtsov Novosibirsk Institute of Organic and Physical Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    S. A. Nizomov, I. V. Sorokina, N. A. Zhukova & T. G. Tolstikova

  2. Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia

    D. E. Semenov

  3. Novosibirsk State Pedagogical University, Novosibirsk, Russia

    A. E. Prosenko

Authors
  1. S. A. Nizomov
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  2. I. V. Sorokina
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  3. N. A. Zhukova
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  4. T. G. Tolstikova
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  5. D. E. Semenov
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  6. A. E. Prosenko
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Corresponding author

Correspondence to I. V. Sorokina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 6, pp. 772-776, June, 2019

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Nizomov, S.A., Sorokina, I.V., Zhukova, N.A. et al. Morphological Assessment of Prostatotropic Activity of (3,5-Dimethyl-4-Hydroxy)Benzyl Thiododecane on a Model of Benign Prostatic Hyperplasia in Rats. Bull Exp Biol Med 167, 809–812 (2019). https://doi.org/10.1007/s10517-019-04628-4

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  • DOI: https://doi.org/10.1007/s10517-019-04628-4

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