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Wave-Like Dose-Dependence of the Stimulating Effects of Dimebon on Cognition in a Wide Dose Range

  • PHARMACOLOGY AND TOXICOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Comparison of the cognition-stimulating effects of Dimebon in a wide dose range revealed a non-monotonic and nontrivial wave-like dose-dependence of its activity. Positive results were obtained at low (0.02-0.05 mg/kg) or high (5-10 mg/kg) doses of Dimebon, while intermediate doses were ineffective. This type of the dose dependence of the pharmacological effect can indicate that the substance has several targets. This fact should be taken into consideration when selecting the doses and concentrations of the substance and its analogues for further studies, and for planning treatment schemes and administration doses in clinical studies.

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Authors and Affiliations

  1. Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia

    N. A. Vasilieva, E. F. Shevtsova, G. I. Van’kin, N. N. Lermontova, T. P. Serkova, N. S. Nikolaeva & S. O. Bachurin

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  1. N. A. Vasilieva
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  2. E. F. Shevtsova
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  3. G. I. Van’kin
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  4. N. N. Lermontova
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  5. T. P. Serkova
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  6. N. S. Nikolaeva
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  7. S. O. Bachurin
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Correspondence to E. F. Shevtsova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 6, pp. 695-699, June, 2019

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Vasilieva, N.A., Shevtsova, E.F., Van’kin, G.I. et al. Wave-Like Dose-Dependence of the Stimulating Effects of Dimebon on Cognition in a Wide Dose Range. Bull Exp Biol Med 167, 740–743 (2019). https://doi.org/10.1007/s10517-019-04612-y

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  • DOI: https://doi.org/10.1007/s10517-019-04612-y

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