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Influence of Age Factor on Respiratory Control of Isolated Cardiomyocytes and Mitochondria in Rats

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We studied the peculiarities of oxidative and substrate phosphorylation in isolated cardiomyocytes and myocardial mitochondria in 2- and 15-month-old rats. It was shown that age factor reduces the degree of oxidation and phosphorylation coupling both in cardiomyocytes and in mitochondria, which was associated with the decrease in the rate of consumption of energy resources.

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Authors and Affiliations

  1. Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    L. P. Tsapko & S. A. Afanas’ev

Authors
  1. L. P. Tsapko
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  2. S. A. Afanas’ev
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Correspondence to L. P. Tsapko.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 4, pp. 435-437, April, 2019

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Tsapko, L.P., Afanas’ev, S.A. Influence of Age Factor on Respiratory Control of Isolated Cardiomyocytes and Mitochondria in Rats. Bull Exp Biol Med 167, 452–454 (2019). https://doi.org/10.1007/s10517-019-04547-4

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  • DOI: https://doi.org/10.1007/s10517-019-04547-4

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