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Effect of If Current Blockade on Newborn Rat Heart Isolated According to Langendorff

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The study examined the effects of hyperpolarization-activated funny current (If) on HR and coronary flow in Langendorff-isolated hearts from newborn rats. Blockade of If current with ZD7288 changed the examined cardiac parameters. The blocker in a concentration of 10—9 M decreased HR by 26.8% (p≤0.05). In concentrations 10—8, 10—7, 10—6, and 10—5 M ZD7288 produced minor differently directed effects. In a concentration of 10—5 M, ZD7288 reduced coronary flow in the isolated heart (p≤0.01). In other concentrations, the blocker produced no significant effects on coronary flow.

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Authors and Affiliations

  1. Department of Human Health Protection, Kazan (Volga region) Federal University, Kazan, Russia

    N. I. Ziyatdinova, A. M. Kuptsova, L. I. Faskhutdinov, A. M. Galieva & T. L. Zefirov

  2. Department of Normal Physiology, Kazan Federal Medical University, Kazan, the republic of Tatarstan, Russia

    A. L. Zefirov

Authors
  1. N. I. Ziyatdinova
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  2. A. M. Kuptsova
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  3. L. I. Faskhutdinov
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  4. A. M. Galieva
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  5. A. L. Zefirov
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  6. T. L. Zefirov
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Corresponding author

Correspondence to T. L. Zefirov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 4, pp. 405-408, April, 2019

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Ziyatdinova, N.I., Kuptsova, A.M., Faskhutdinov, L.I. et al. Effect of If Current Blockade on Newborn Rat Heart Isolated According to Langendorff. Bull Exp Biol Med 167, 424–427 (2019). https://doi.org/10.1007/s10517-019-04541-w

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  • DOI: https://doi.org/10.1007/s10517-019-04541-w

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