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Combination of Mesenchymal Stromal Cells and Cardiac Stem Cells in a Multilayer Cell Construct Promotes Activation of Notch Signaling and Initiation of Endothelial Differentiation

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We showed the possibility of generating combined tissue-engineered cell consisting of layers of rat cardiac stem cells and mesenchymal stromal cells from the adipose tissue. Cell—cell interaction within the cell sheet promoted proliferation of cardiac stem cells, expression of endothelial differentiation marker ETS1, and Notch signaling activation. The obtained results provide new insights into possible mechanisms of stimulation of endogenous regeneration processes after myocardial damage and demonstrate potential of cell-based cardiomyoplasty with the use of these combined cell sheets.

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Authors and Affiliations

  1. National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia

    E. K. Shevchenko, K. V. Dergilev, Z. I. Tsokolaeva, I. B. Beloglazova, Yu. D. Molokotina, E. V. Parfenova & M. Yu. Men’shikov

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  1. E. K. Shevchenko
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  2. K. V. Dergilev
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  3. Z. I. Tsokolaeva
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  4. I. B. Beloglazova
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  5. Yu. D. Molokotina
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  6. E. V. Parfenova
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  7. M. Yu. Men’shikov
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Corresponding author

Correspondence to E. K. Shevchenko.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 233-238, December, 2018

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Shevchenko, E.K., Dergilev, K.V., Tsokolaeva, Z.I. et al. Combination of Mesenchymal Stromal Cells and Cardiac Stem Cells in a Multilayer Cell Construct Promotes Activation of Notch Signaling and Initiation of Endothelial Differentiation. Bull Exp Biol Med 166, 548–552 (2019). https://doi.org/10.1007/s10517-019-04390-7

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  • DOI: https://doi.org/10.1007/s10517-019-04390-7

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