Predictive models of comorbidity, dyslipidemic disorders and essential arterial hypertension, in Russian adolescents aged 12 to 18 years (mean 15.48±1.53) were formulated with consideration for biochemical (lipid profiles) and genetic parameters (carrier state of gene polymorphic variants of apolipoprotein genes ApoA1 (-75G/A and +83C/T), ApoB (Ins/Del), ApoC3 (S1/S2), and ApoE (ε2/ε3/ε4). Significant prognostic risk factors for the mentioned comorbid pathologies were lipid metabolism parameters HDL-Ch, LDL-Ch, VLDL-Ch and carrier state of the +83T allele of the ApoA1 gene and Del allele of the ApoB gene. The obtained mathematical model is characterized by high predictive accuracy: the percentage of correct classification or the rate of correct assignment of each participant to the proper group was 96.33%.
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Bairova TA, Dolgikh VV, Kolesnikova LI, Kosovtseva AS, Sholokhov LF. The gene of alpha2a-adrenoreceptor and essential arterial hypertension. Ross. Kardiol. Zh. 2014;19(11):7-12. Russian.
Bureeva NN. Multivariate Statistical Analysis with the Use of Application Software Package “Statistica”. Nizhny Novgorod, 2007. Russian.
Vologdina IO, Bimbayev AB-Zh, Bairova TА, Tugutova IV, Bulavko VK. Metabolic derangements in teenagers having essential arterial 90 hypertension. Acta Biomedica Scientifica. 2007;(5):90-91. Russian.
Vologdina IO, Dolgikh VV, Bimbaev AB-Zh, Bairova TA. Prognostic amount of risk factors in arterial hypertension forming among schoolchildren of Buryatya Republic. Acta Biomedica Scientifica. 2009;(2):19-21. Russian.
Dolgikh VV, Bol’shakova SE, Kolesnikova LI, Mikhalevich IM. Molecular genetic markers of predisposition to thrombosis in adolescents with essential hypertension. Ter. Arkhiv. 2014;86(9):45-48. Russian.
Ershova OA, Bairova TA, Kolesnikov SI, Kalyuzhnaya OV, Darenskaya MA, Kolesnikova LI. Oxidative Stress and Catalase Gene. Bull. Exp. Biol. Med. 2016;161(3):400-403.
Kalyuzhnaya OV, Bairova TA, Kolesnikova LI. Gene-Gene Interactions of Apolipoprotein Gene Polymorphic Variants in Adolescents with Essential Arterial Hypertension and Dyslipidemia. Bull. Exp. Biol. Med. 2017;163(4):456-460.
Inge-Vechtomov SG. From chromosome theory to the template principle. Russ. J. Genetics. 2015;51(4):323-333.
Belyaeva E, Rychkova L, Bairova T, Kolesnikova L. Changes in circadian organization of blood pressure levels in children with chronic glomerulonephritis and secondary hypertension depending on the genotype of the AGTR1 gene. Arch. Dis. Childhood. 2017;102(S2):A92-A93. doi: https://doi.org/10.1136/archischaild-2017-313273.188.
Halperin RO, Sesso HD, Ma J, Buring JE, Stampfer MJ, Gaziano JM. Dyslipidemia and the risk of incident hypertension in men. Hypertension. 2006;47(1):45-50.
Kaluzhnaya O, Rychkova L, Bairova T, Bugun O, Kolesnikova L. Apolipoprotein B gene as risk marker of dyslipidemia for teenagers with essential hypertension. Arch. Dis. Childhood. 2017;102(S2):A51-A52. doi: https://doi.org/10.1136/archdischild-2017-313273.132.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 8, pp. 261-264, August, 2018
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Kalyuzhnaya, O.V., Bairova, T.A. & Kolesnikova, L.I. Predictive Models for the Risk of Dyslipidemia in Adolescents with Essential Arterial Hypertension. Bull Exp Biol Med 166, 297–300 (2018). https://doi.org/10.1007/s10517-018-4336-y
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DOI: https://doi.org/10.1007/s10517-018-4336-y