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Effects of Neostigmine and Physostigmine on Activity of Na+,K+-ATPase in Various Subdivisions of Rat Brain

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The effects of intramuscular administration of neostigmine and physostigmine on Na+,K+-ATPase activity in various cerebral subdivisions were examined in rats. In CNS and peripheral tissues, both agents rapidly and significantly reduced activity of cholinesterases by 30-50%. The development of intoxication did not change the marker indices of stress reaction. In the cerebral cortex, physostigmine increased Na+,K+-ATPase activity, whereas neostigmine suppressed it. In addition, neostigmine decreased activity of this enzyme in the cerebellum. In contrast, both agents produced no effects on Na+,K+-ATPase activity in the striatum. The data corroborate the view on functional interaction between Na+,K+-ATPase and nicotinic cholinoreceptors in rat cerebral cortex.

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Authors and Affiliations

  1. Tyumen State University, Tyumen, Russia

    V. N. Dubrovskii, A. D. Shalabodov & A. V. Belkin

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  1. V. N. Dubrovskii
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  2. A. D. Shalabodov
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  3. A. V. Belkin
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Correspondence to V. N. Dubrovskii.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 7, pp. 58-61, July, 2018

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Dubrovskii, V.N., Shalabodov, A.D. & Belkin, A.V. Effects of Neostigmine and Physostigmine on Activity of Na+,K+-ATPase in Various Subdivisions of Rat Brain. Bull Exp Biol Med 166, 50–53 (2018). https://doi.org/10.1007/s10517-018-4287-3

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  • DOI: https://doi.org/10.1007/s10517-018-4287-3

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