Metabolism of a novel anxiolytic GML-1 (N-benzyl-N-methyl-1-phenylpyrrolo[1,2-a]pirazin-3-carboxamide) in rat blood plasma was studied by HPLC-mass spectrometry. Three biotransformation products with the corresponding molecular ions were detected. A conclusion was made that the main pathways of GML-1 metabolism are oxidative reactions yielding hydroxylated, methylated, and demethylated metabolites.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 6, pp. 709-711, June, 2018
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Novitskii, A.A., Bochkov, P.O., Shevchenko, R.V. et al. Metabolism of a Novel Anxiolytic GML-1 in Rats. Bull Exp Biol Med 165, 751–753 (2018). https://doi.org/10.1007/s10517-018-4257-9
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DOI: https://doi.org/10.1007/s10517-018-4257-9