Abstract
An open, single, crossover, pharmacokinetic study of GML-1 (dose 50 mg/kg) in rabbits after its oral administration in tablets and alone as a substance is carried out. The following pharmacokinetic parameters are calculated: the maximum concentration of GML-1 in blood plasma (Cmax) of rabbits, the time required to reach Cmax, the area under the concentration-time curve, the half-time of GML-1, and the relative bioavailability. The GML-1 concentration is detected with the use of the HPLC-MS (ion trap) by the daughter ions. The relative bioavailability of GML-1 in tablets is 101.72 ± 19.96% in comparison to the substance.
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Funding
This study was supported by the Ministry of Education and Science (state contract no. 14. N08.12.0087).
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Statement on the welfare of animals. All applicable international, national and/or institutional principles for the care and use of animals were followed.
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Translated by M. Novikova
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Novitskiy, A.A., Litvin, A.A., Shevchenko, R.V. et al. Comparative Pharmacokinetics and Relative Bioavailability of a New Anxiolytic GML-1 in Tablet Form. Moscow Univ. Chem. Bull. 74, 204–207 (2019). https://doi.org/10.3103/S0027131419040060
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DOI: https://doi.org/10.3103/S0027131419040060