Skip to main content
SpringerLink
Log in

Concentrations of Gaseous Transmitters during Catecholamine Damage to the Myocardium in Rats

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Gaseous transmitters were assayed in rat blood during catecholamine-induced damage to the heart. Hypercatecholaminemia was modeled by single subcutaneous injection of 0.1% epinephrine hydrochloride in a dose of 2 mg/kg. The blood concentrations of NO, H2S, and CO were measured. The catecholamine-induced damage to the myocardium resulted in phasic changes in the blood levels of gaseous transmitters: CO concentration increased in 1 h, H2S increased in 24 h, and NO concentration increased in 72 h after injection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kursov SV, Beletskiy OV, Lyzogub KI, Lyzogub MV. Blood carboxyhemoglobin monitoring for evaluation of severity of traumatic shock and reperfusion injuries (analytical review with results of our own observations). Medistina Neotlozhnykh Sostoyanii. 2017;(1):32-38. Russian.

    Article  Google Scholar 

  2. Makarenko EV, Pimanov SI, Chupakhina OP, Shilenok AV, Kut’ko SE, Pilant DA. Stress-induced (takotsubo) cardiomyopathy. Vestn. Vitebsk. Gos. Med. Univer. 2012;11(1):157-165. Russian.

    Google Scholar 

  3. Khidirova LD, Mayanskaya NN. Inflammatory reactions in experimental myocardial damage. Rats. Farmakoter. Kardiol. 2012;8(5):717-720. Russian.

    Article  Google Scholar 

  4. Beutler E, West C. Simplified determination of carboxyhemoglobin. Clin. Chem. 1984;30(6):871-874.

    CAS  PubMed  Google Scholar 

  5. Guo SB, Duan ZJ, Wang QM, Zhou Q, Li Q, Sun XY. Endogenous carbon monoxide downregulates hepatic cystathionine-γ-lyase in rats with liver cirrhosis. Exp. Ther. Med. 2015;10(6):2039-2046.

    Article  CAS  Google Scholar 

  6. King AL, Polhemus DJ, Bhushan S, Otsuka H, Kondo K, Nicholson CK, Bradley JM, Islam KN, Calvert JW, Tao YX, Dugas TR, Kelley EE, Elrod JW, Huang PL, Wang R, Lefer DJ. Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent. Proc. Natl Acad. Sci. USA. 2014;111(8):3182-3187.

    Article  CAS  Google Scholar 

  7. Kobayashi A, Mizukami H, Sakamoto N, Yamaki T, Kunii H, Nakazato K, Takeishi Y. Endogenous carbon monoxide concentration in blood elevates in acute coronary syndrome of nonsmoker population. Fukushima J. Med. Sci. 2015;61(1):72-78.

    Article  CAS  Google Scholar 

  8. Miranda KM, Espey MG, Wink DA. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide. 2001;5(1):62-71.

    Article  CAS  Google Scholar 

  9. Oh GS, Pae HO, Lee BS, Kim BN, Kim JM, Kim HR, Jeon SB, Jeon WK, Chae HJ, Chung HT. Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide. Free Radic. Biol. Med. 2006;41(1):106-119.

    Article  CAS  Google Scholar 

  10. Qu K, Chen CP, Halliwell B, Moore PK, Wong PT. Hydrogen sulfide is a mediator of cerebral ischemic damage. Stroke. 2006;37(3):889-893.

    Article  CAS  Google Scholar 

  11. Rose P, Moore PK, Zhu YZ. H2S biosynthesis and catabolism: new insights from molecular studies. Cell. Mol. Life Sci. 2017;74(8):1391-1412.

    Article  CAS  Google Scholar 

  12. Stein AB, Bolli R, Dawn B, Sanganalmath SK, Zhu Y, Wang OL, Guo Y, Motterlini R, Xuan YT. Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium. J. Mol. Cell. Cardiol. 2012;52(1):228-236.

    Article  CAS  Google Scholar 

  13. Wang J, Lu S, Moënne-Loccoz P, Ortiz de Montellano PR. Interaction of nitric oxide with human heme oxygenase-1. J. Biol. Chem. 2003;278(4):2341-2347.

    Article  CAS  Google Scholar 

  14. Wang R. Shared signaling pathways among gasotransmitters. Proc. Natl Acad. Sci. USA. 2012;109(23):8801-8802.

    Article  CAS  Google Scholar 

  15. Whiteman M, Li L, Kostetski I, Chu SH, Siau JL, Bhatia M, Moore PK. Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide. Biochem. Biophys. Res. Commun. 2006;343(1):303-310.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Ivanovo State Medical Academy, Ministry of Health of the Russian Federation, Ivanovo, Russia

    A. S. Ivanova & S. B. Nazarov

  2. V. N. Gorodkov Ivanovo Research Institute of Maternal and Child Health Care, Ministry of Health of the Russian Federation, Ivanovo, Russia

    O. G. Sitnikova, I. G. Popova & S. B. Nazarov

Authors
  1. A. S. Ivanova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. G. Sitnikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. G. Popova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. B. Nazarov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. S. Ivanova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 6, pp. 681-683, June, 2018

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ivanova, A.S., Sitnikova, O.G., Popova, I.G. et al. Concentrations of Gaseous Transmitters during Catecholamine Damage to the Myocardium in Rats. Bull Exp Biol Med 165, 725–727 (2018). https://doi.org/10.1007/s10517-018-4251-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-018-4251-2

Key Words

Search

Navigation