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Effect of Intramuscular Administration of Mesenchymal Stem Cells and Erythropoietin on Angiogenesis in Critical Limb Ischemia

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of intramuscular injections of bone marrow mesenchymal stromal cells on microcirculation parameters in an ischemic limb of Wistar rats. It was shown that transplantation of mesenchymal stem cells with or without erythropoietin stimulates angiogenesis in the ischemic zone. An essential role in angiogenesis stimulation is played by cytokines and growth factors.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    A. P. Lykov, N. A. Bondarenko, O. V. Poveshchenko, A. V. Kabakov, M. A. Surovtseva, I. I. Kim, O. V. Kazakov & A. F. Poveshchenko

Authors
  1. A. P. Lykov
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  2. N. A. Bondarenko
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  3. O. V. Poveshchenko
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  4. A. V. Kabakov
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  5. M. A. Surovtseva
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  6. I. I. Kim
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  7. O. V. Kazakov
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  8. A. F. Poveshchenko
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Corresponding author

Correspondence to A. P. Lykov.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 10-14, January, 2018

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Lykov, A.P., Bondarenko, N.A., Poveshchenko, O.V. et al. Effect of Intramuscular Administration of Mesenchymal Stem Cells and Erythropoietin on Angiogenesis in Critical Limb Ischemia. Bull Exp Biol Med 165, 121–126 (2018). https://doi.org/10.1007/s10517-018-4112-z

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  • DOI: https://doi.org/10.1007/s10517-018-4112-z

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