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Pathogenetic Role of Endothelial Dysfunction in Idiopathic Vestibulopathy

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Bulletin of Experimental Biology and Medicine Aims and scope

Comparative analysis of the groups of patients with idiopathic bilateral vestibular hypofunction and a group of vestibulopathy patients with vertebrobasilar insufficiency demonstrated identity of the basic and additional diagnostic parameters in these syndromes as well as similarity in clinical diagnostic and anamnesis data. In all cases, functional assessment of endothelium-dependent vasodilation and selected biochemical marker sICAM-1 revealed endothelial dysfunction. Drug correction of endothelial dysfunction positively affected the manifestations of major and minor features of the syndrome, which confirmed the contribution of endothelial functional disturbances to the pathogenesis of bilateral vestibular hypofunction.

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Authors and Affiliations

  1. National Research Tomsk State University, Tomsk, Russia

    E. V. Udut, P. P. Shchetinin, T. V. Rudenko, H. Kingma, A. P. Shchetinina, M. O. Pleshkov, V. P. Demkin & V. V. Udut

  2. Department of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, School for Mental Health and Neuroscience, Maastricht, the Netherlands

    F. Lucieer & H. Kingma

  3. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    E. V. Udut & V. V. Udut

Authors
  1. E. V. Udut
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  2. P. P. Shchetinin
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  3. T. V. Rudenko
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  4. F. Lucieer
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  5. H. Kingma
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  6. A. P. Shchetinina
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  7. M. O. Pleshkov
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  8. V. P. Demkin
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  9. V. V. Udut
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Corresponding author

Correspondence to E. V. Udut.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 12, pp. 692-696, December, 2017

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Udut, E.V., Shchetinin, P.P., Rudenko, T.V. et al. Pathogenetic Role of Endothelial Dysfunction in Idiopathic Vestibulopathy. Bull Exp Biol Med 164, 726–729 (2018). https://doi.org/10.1007/s10517-018-4067-0

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  • DOI: https://doi.org/10.1007/s10517-018-4067-0

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