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Behavior Disorders Caused by Perinatal Hypoxia in Juvenile Rats and Their Correction with GABA Derivative

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We studied the effects of acute normobaric hypoxia on postnatal day 2 (model of preterm pregnancy) on reflex activity and behavior of juvenile male Wistar rats and the possibility of correction of behavioral deficit by administration of GABA derivative Salifen after hypoxia. It is shown, that perinatal hypoxia impaired righting reflex and forelimb grip strength and increased motor activity in juvenile male rats. Administration of Salifen for 14 days in a dose of 15 mg/kg improved reflex activity and behavior of rats, which indicates the prospect of further study of the therapeutic efficacy of this drug on models of neonatal encephalopathy.

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Authors and Affiliations

  1. Laboratory of Ontogenesis of the Nervous System, St. Petersburg, Russia

    N. E. Ordyan & V. A. Otellin

  2. Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology of the Russian Academy of Sciences, St. Petersburg, Russia

    V. K. Akulova & V. I. Mironova

Authors
  1. N. E. Ordyan
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  2. V. K. Akulova
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  3. V. I. Mironova
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  4. V. A. Otellin
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Correspondence to N. E. Ordyan.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 8, pp. 140-144, August, 2017

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Ordyan, N.E., Akulova, V.K., Mironova, V.I. et al. Behavior Disorders Caused by Perinatal Hypoxia in Juvenile Rats and Their Correction with GABA Derivative. Bull Exp Biol Med 164, 118–122 (2017). https://doi.org/10.1007/s10517-017-3938-0

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  • DOI: https://doi.org/10.1007/s10517-017-3938-0

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