Effect of alkoxyamines on normal and tumor cells was studied in vitro and in vivo. In vitro experiments showed that alkoxyamines produce a dose-dependent toxic effect on cells of human breast tumor MCF7 line. Transplantation of Krebs-2 ascites carcinoma cells preincubated with alkoxyamines to mice did not induce tumor growth. An opposite effect was observed in normal mouse cells: functional activity of peritoneal macrophages increased. The possibility of using alkoxyamines as theranostic agents is discussed.
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24 May 2018
The author name M. V. Edeeva should read M. V. Edeleva.
References
Devadasu VR, Bhardwaj V, Kumar MN. Can controversial nanotechnology promise drug delivery? Chem. Rev. 2013;113(3):1686-1735.
Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, Forman D, Bray F. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur. J. Cancer. 2013;49(6):1374-1403.
Kaledin VI, Popova NA, Nikolin VP, Vasilieva ED, Kirilyuk IA, Grigor’ev IA. Tempol reduces the therapeutic effect of cyclophosphamide on an experimental tumor model. Free Radic. Res. 2009;43(7):685-690.
Kelkar SS, Reineke TM. Theranostics: combining imaging and therapy. Bioconjug. Chem. 2011;22(10):1879-1903.
Kirilyuk IA, Kaledin VI, Popova NA, Nikolin VP, Vasil’eva ED, Grigor’ev IA, Lushnikova EL, Nepomnyashchikh L.M. Nitroxyl antioxidant TPPA-TEMPO increases the efficacy of antitumor therapy on the model of transplantable mouse tumor. Bull. Exp. Biol. Med. 2010;150(1):75-78.
Kovtun GA, Aleksandrov AL, Golubev VA. Interaction of peroxide radicals with esters of hydroxylamines. Russ. Chem. Bull. 1974;23(10):2115-2121.
Moncelet D, Voisin P, Koonjoo N, Bouchaud V, Massot P, Parzy E, Audran G, Franconi JM, Thiaudière E, Marque SR, Brémond P, Mellet P. Alkoxyamines: Toward a new family of theranostic agents against cancer. Mol. Pharm. 2014;11(7):2412-2419.
Ozben T. Oxidative stress and apoptosis: impact on cancer therapy. J. Pharm. Sci. 2007;96(9):2181-2196.
Popova NA, Kaledin VI, Nikolin VP, Sysoeva GM, Yuzhik EI, Lushnikova EL, Nepomnyashchikh LM, Kirilyuk IA, Grigor’ev IA. The Influence of nitroxyl radical 4-triphenylphosphonioacetamido-2,2,6,6-tetramethylpiperidine-l-oxyl (tppa-tempo) on general toxicity and therapeutic efficiency of cyclophosphamide on transplantable mouse lymphosarcoma ls in vitro and in vivo. Int. J. Med. Pharm. Sci. 2016;6(1):9-22.
Ross JS, Ginsburg GS. The integration of molecular diagnostics with therapeutics. Implications for drug development and pathology practice. Am. J. Clin. Pathol. 2003;119(1):26-36.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 7, pp. 61-65, July, 2017
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Popova, N.A., Sysoeva, G.M., Nikolin, V.P. et al. Comparative Study of Toxicity of Alkoxyamines In Vitro and In Vivo . Bull Exp Biol Med 164, 49–53 (2017). https://doi.org/10.1007/s10517-017-3924-6
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DOI: https://doi.org/10.1007/s10517-017-3924-6