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Effect of Lipid Surface Composition on the Formation and Structure of Fibrin Clots

  • BIOPHYSICS AND BIOCHEMISTRY
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the influence of lipid surface composition on the kinetics of fibrin clot formation and its structure. It was shown that lipid surface affects all phases of fibrin polymerization and chances clot morphology. The magnitude and character of the effect depend on the charge and phase state of lipids that determine the interaction of fibrinogen with the lipid surface and its conformational changes, which modulated the process of fibrinogen conversion into fibrin and, as a result, the formation and morphology of the fibrin clot.

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Authors and Affiliations

  1. Kazan Institute of Biochemistry and Biophysics, Kazan Research Center, Russian Academy of Science, Kazan, Russia

    D. R. Bakirova, D. A. Faizullin, Yu. A. Valiullina, V. V. Salnikov & Yu. F. Zuev

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  1. D. R. Bakirova
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  2. D. A. Faizullin
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  3. Yu. A. Valiullina
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  4. V. V. Salnikov
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  5. Yu. F. Zuev
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Correspondence to D. R. Bakirova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 6, pp. 687-690, June, 2017

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Bakirova, D.R., Faizullin, D.A., Valiullina, Y.A. et al. Effect of Lipid Surface Composition on the Formation and Structure of Fibrin Clots. Bull Exp Biol Med 163, 722–725 (2017). https://doi.org/10.1007/s10517-017-3889-5

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  • DOI: https://doi.org/10.1007/s10517-017-3889-5

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