We studied radioprotective effects of a preparation based on yeast RNA and its influence on therapeutic efficiency of ionizing radiation against transplanted tumors. Parenteral administration of yeast RNA preparation to mice in a dose of 10 mg 1 h prior to exposure to ionizing γ-radiation (137Cs) in a lethal dose (LD80/30) increased 30-day survival by 66%; by day 80, 80% of animals survived (vs. 2.5% in the control). Whole-body exposure to ionizing γ-radiation in a dose of 7 Gy significantly increased the mean lifespan of mice with experimental lung metastases or intraperitoneally transplanted leukemia L-1210 by 42 and 20.8%, respectively. RNA preparation injected to the mice with tumors 1 h before irradiation did not affect the therapeutic efficiency of ionizing radiation or significantly potentiated it (in mice with transplanted leukemia L-1210). These results suggest that yeast RNA preparation protects healthy tissues during radiotherapy of malignant tumors.
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Podgornyi VF, Gur’ev VP, Klimenko VP, Podgornyi NM, Zagrebel’nyi SN. Inventor’s certificate SU 936701 A. A method for isolation of high-polymer RNA from yeast. Bull. No. 15. Published April 23, 1985. Russian.
Yamkovaya TV, Kolesnikova OP, Yamkovoy VI, Kozlov VA, Panin LE. Immunotropic activity of soapy amphiphilic highpolymer RNA from baker’s yeast. Byull. Sib. Otdel. Ross. Akad. Med. Nauk. 2013;33(4):42-48. Russian.
Yamkovaya TV, Yamkovoi VI, Panin LE. Biological activity of different RNA preparations from baking yeast. Byull. Sib. Otdel. Ross. Akad. Med. Nauk. 2006;26(3):117-121. Russian.
Citrin D, Cotrim AP, Hyodo F, Baum BJ, Krishna MC, Mitchell JB. Radioprotectors and mitigators of radiation-induced normal tissue injury. Oncologist. 2010;15(4):360-371.
Kma L. Plant extracts and plant-derived compounds: promising players in a countermeasure strategy against radiological exposure. Asian Pac. J. Cancer Prev. 2014;15(6):2405-2425.
Langell J, Jennings R, Clark J, Ward JB Jr. Pharmacological agents for the prevention and treatment of toxic radiation exposure in spaceflight. Aviat. Space Environ. Med. 2008;79(7):651-660.
Maier P, Wenz F, Herskind C. Radioprotection of normal tissue cells. Strahlenther Onkol. 2014;190(8):745-752.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 5, pp. 596-599, May, 2017
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Nikolin, V.P., Bogachev, S.S., Popova, N.A. et al. Experimental Study of Yeast RNA Preparation as a Possible Radioprotective Agent for Radiotherapy of Malignant Tumors. Bull Exp Biol Med 163, 639–642 (2017). https://doi.org/10.1007/s10517-017-3868-x
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DOI: https://doi.org/10.1007/s10517-017-3868-x