The active ingredient extracted from the peat humic substances was characterized by physicochemical parameters evaluated by UV- and IR-spectroscopy, titration, and elemental (C, H, N) analysis. The cardiovascular effects of this ingredient were examined on isolated Langendorff-perfused rat heart. It was found that the active substance in a concentration range of 0.01-0.1 mg/ml produced a vasodilating effect; in addition, it decreased the end-diastolic and left-ventricular developed pressures.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 2, pp. 167-170, February, 2017
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Zykova, M.V., Belousov, M.V., Lasukova, T.V. et al. Cardiovascular Effects of High-Molecular-Weight Compounds of Humic Nature. Bull Exp Biol Med 163, 206–209 (2017). https://doi.org/10.1007/s10517-017-3767-1
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DOI: https://doi.org/10.1007/s10517-017-3767-1