In vitro production of immunoregulatory cytokines (IFN-α, IL-31, TNF-β, IL-17A, IL-7, IL-1RA, IL-1α, IL-10, IL-15, IL-21, IL-22, IL-23, IL-27, and IL-9) by dendritic cell cultures was compared in ski athletes and healthy donors. Effect of prolonged intense physical exercise on secretory activity of immune cells was investigated. In both groups, secretion of IL-1RA, IL-10, IL-1α by dendritic cells was revealed, but there were significant differences in IL-1RA, IL-1α content (p<0.05) with lower level in the group of athletes. Production of IL-17A and IL-7 by dendritic cells in the group of athletes was not detected. In athletes, several proinflammatory cytokines (IFN-α, IL-31, and TNF-β) were secreted by cells in high concentrations, in contrast to the control group. In both groups, dendritic cells did not secrete IL-15, IL-21, IL-22, IL-23, IL-27, and IL-9.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Pashenkov MV, Plnegln BV. Cell physiology of innate immune system: dendritic cells. Immunologiya. 2006;27(6):368-378. Russian.
Blannin AK. Acute exercise and innate immune function. Immune function in sport and exercise. Gleeson M, ed. Edinburgh, 2006. P. 67-89.
Gleeson M. Immune function in sport and exercise. J. Appl. Physiol. 2007;103(2):693-699.
Horejs-Hoeck J, Schwarz H, Lamprecht S, Maier E, Hainzl S, Schmittner M, Posselt G, Stoecklinger A, Hawranek T, Duschl A. Dendritic cells activated by IFN-g/STAT1 express IL-31 receptor and release proinflammatory mediators upon IL-31 treatment. J. Immunol. 2012;188(11):5319-5326.
Hubert P, Jacobs N, Caberg JH, Boniver J, Delvenne P. The cross-talk between dendritic and regulatory T cells: good or evil? J. Leukoc. Biol. 2007;82(4):781-794.
MacIntyre DL, Reid WD, McKenzie DC. Delayed muscle soreness. The inflammatory response to muscle injury and its clinical implications. Sports Med. 1995;20(1):24-40.
Morgado J.M, Rama L, Silva I, de Jesus Inácio M, Henriques A, Laranjeira P, Pedreiro S, Rosado F, Alves F, Gleeson M, Pais ML, Paiva A, Teixeira AM. Cytokine production by monocytes, neutrophils, and dendritic cells is hampered by long-term intensive training in elite swimmers. Eur. J. Appl. Physiol. 2012;112(2):471-482.
Nobbe S, Dziunycz P, Mühleisen B, Bilsborough J, Dillon SR, French LE, Hofbauer GF. IL-31 expression by inflammatory cells is preferentially elevated in atopic dermatitis. Acta Derm. Venerol. 2012;92(1):24-28.
Parker JC, Thavagnanam S, Skibinski G, McBrien M, Heaney LG, Shields D. IL-31 does not induce normal human ciliated epithelial cells to differentiate into a phenotype consistent with the pathophysiology of asthma. Results Immunol. 2012;2:104-111.
Pedersen BK, Hoffman-Goetz L. Exercise and the immune system: regulation, integration, and adaptation. Physiol. Rev. 2000;80(3):1055-1081.
Scott JP, Sale C, Greeves JP, Casey A, Dutton J, Fraser WD. Cytokine response to acute running in recreationallyactive and endurance-trained men. Eur. J. Appl. Physiol. 2013;113(7):1871-1882.
Simpson RJ, Kunz H, Agha N, Graff R. Exercise and the regulation of immune functions. Prog. Mol. Biol. Transl Sci. 2015;135:355-380.
Smith LL. Acute inflammation: the underlying mechanism in delayed onset muscle soreness? Med. Sci. Sports Exerc. 1991;23(5):542-551.
Spence L, Brown WJ, Pyne DB, Nissen MD, Sloots TP, Mc-Cormack JG, Locke AS, Fricker PA. Incidence, etiology, and symptomatology of upper respiratory illness in elite athletes. Med. Sci. Sports Exerc. 2007;39(4):577-586.
Suchánek O, Podrazil M, Fischerová B, Bočínská H, Budínský V, Stejskal D, Spíšek R, Bartůňková J, Kolář P. Intensive physical activity increases peripheral blood dendritic cells. Cell Immunol. 2010;266(1):40-45.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 7, pp. 72-74, July, 2016
Rights and permissions
About this article
Cite this article
Evstratova, V.S., Nikityuk, D.B., Riger, N.A. et al. Evaluation In Vitro of Immunoregulatory Cytokines Secretion by Dendritic Cells in Mountain Skiers. Bull Exp Biol Med 162, 60–62 (2016). https://doi.org/10.1007/s10517-016-3545-5
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-016-3545-5