Abstract
Cell immunity indices were studied in 6 female participants in the Moon-2015 project at the age of 25 to 34 years. Peripheral blood was analyzed for lymphocyte subtypes CD3+, CD3+CD4+, CD3+CD8+, CD19+, and CD3–CD16+CD56+ and monocytes and granulocytes that express signal recognition receptors of the Toll-like (TLR) family (TLR2, TLR4, TLR6) localized on the surface of cells. The results of the study have demonstrated a distinct effect of short-term isolation on the immune system ability to mobilize. Rotation on a short-arm centrifuge (SAC) together with a nine-day isolation in a chamber caused diverse responses of the adaptive and innate immune systems. Apparently, the changes observed reflect a complex adaptation process in the innate and acquired immunity at the early stage of adaptation to isolation and also to the exposure to +Gz accelerations (head-to-pelvis) during rotations on SAC.
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ACKNOWLEDGMENTS
The study was partly supported by the Grant of the President of the Russian Federation for Support of Leading Scientific Schools “Molecular and Cellular Mechanisms of Microgravity Effects”, project no. 7479.2016.4.
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Ponomarev, S.A., Muranova, A.V., Kalinin, S.A. et al. Cell Immunity Indices in Crew Members of the Moon-2015 Project. Hum Physiol 44, 799–805 (2018). https://doi.org/10.1134/S0362119718070125
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DOI: https://doi.org/10.1134/S0362119718070125