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Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss

  • PHARMACOLOGY AND TOXICOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

The leading role in the regulation of erythropoietic activity of adherent bone marrow cells under conditions of post-hemorrhagic anemia is played by classical MAP kinase pathway (ERK pathway). Erythropoietin is not the decisive factor in the formation of erythropoietic activity of adherent cells. PI3K, MAPK/ERK 1/2, and p38-signaling proteins are not the main regulators of local production of erythropoietin after 30% loss of circulating blood volume.

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia

    V. V. Zhdanov, L. A. Miroshnichenko, E. V. Udut, G. N. Zyuz’kov, T. Yu. Khrichkova, E. V. Simanina, E. Yu. Sherstoboev, L. A. Stavrova, V. I. Agafonov, A. V. Chaikovskii, M. Yu. Minakova & A. M. Dygai

Authors
  1. V. V. Zhdanov
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  2. L. A. Miroshnichenko
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  3. E. V. Udut
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  4. G. N. Zyuz’kov
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  5. T. Yu. Khrichkova
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  6. E. V. Simanina
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  7. E. Yu. Sherstoboev
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  8. L. A. Stavrova
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  9. V. I. Agafonov
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  10. A. V. Chaikovskii
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  11. M. Yu. Minakova
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  12. A. M. Dygai
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Corresponding author

Correspondence to L. A. Miroshnichenko.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 7, pp. 62-66, July, 2016

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Zhdanov, V.V., Miroshnichenko, L.A., Udut, E.V. et al. Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss. Bull Exp Biol Med 162, 51–55 (2016). https://doi.org/10.1007/s10517-016-3543-7

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  • DOI: https://doi.org/10.1007/s10517-016-3543-7

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