We studied the role of signaling pathways in the regulation of erythropoiesis against the background of myelosuppression caused by administration of 5-fluorouracil. The important role of cyclic AMP in the maturation of erythroid progenitors after cytostatic treatment was demonstrated. The secretory activity of myelokaryocytes during the period of erythroid hemopoiesis recovery is mainly regulated via the p38 MAPK signaling pathway; non-erythropoietin factors are involved in the formation of erythropoietic activity of adherent cells of the microenvironment.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 9, pp. 282–286, September, 2014
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Dygai, A.M., Zhdanov, V.V., Miroshnichenko, L.A. et al. Participation of Signaling Cascades in the Regulation of Erythropoiesis under Conditions of Cytostatic Treatment. Bull Exp Biol Med 158, 304–307 (2015). https://doi.org/10.1007/s10517-015-2747-6
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DOI: https://doi.org/10.1007/s10517-015-2747-6