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Pro- and Antioxidant Systems in the Lower Portion of Rat Brainstem during Hydroxybutyrate-Induced Pathological Periodic Breathing

  • GENERAL PATHOLOGY AND PATHOPHYSIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Activities of superoxide dismutase and catalase characterizing antioxidant status of the nervous tissue and its resistance to free radical oxidation were measured in the brainstem of rats with hydroxybutyrate-induced pathological periodic breathing. Hydroxybutyrate modified the pro- and antioxidant status in the brainstem respiratory center. It markedly inhibited catalase activity; in rats without the signs of periodic breathing, hydroxybutyrate up-regulated superoxide dismutase activity and to a lesser extent increased the resistance of the membrane structures in the medulla oblongata to induction of free radical oxidation. In rats with periodic breathing pattern, hydroxybutyrate induced more pronounced increase in the sensitivity of membrane structures in the medulla oblongata to induction of free radical oxidation.

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Authors and Affiliations

  1. Laboratory of General Pathology of Cardiorespiratory System, Research Institute of General Pathology and Pathological Physiology, Moscow, Russia

    I. A. Tarakanov, L. N. Tikhomirova & N. F. Safina

  2. Laboratory of Experimental Hygienic Studies, Research Institute for Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, Russia

    A. G. Zhukova

Authors
  1. I. A. Tarakanov
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  2. L. N. Tikhomirova
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  3. A. G. Zhukova
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  4. N. F. Safina
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Corresponding author

Correspondence to I. A. Tarakanov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 7, pp. 19-23, July, 2016

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Tarakanov, I.A., Tikhomirova, L.N., Zhukova, A.G. et al. Pro- and Antioxidant Systems in the Lower Portion of Rat Brainstem during Hydroxybutyrate-Induced Pathological Periodic Breathing. Bull Exp Biol Med 162, 14–17 (2016). https://doi.org/10.1007/s10517-016-3533-9

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  • DOI: https://doi.org/10.1007/s10517-016-3533-9

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