The effects of melatonin on the interaction between the level of accumulation of oxidatively modified proteins, the activity of antioxidant enzymes, and the state of the proteolysis system in the basal ganglia (caudate nucleus, globus pallidus, nucleus accumbens, amygdaloid complex) of the brain were studied in conditions of acute hypoxia. Acute hypoxia was found to increase protein peroxidation and proteolysis intensity in the basal ganglia, and also to decrease the activity of antioxidant defense enzymes. Administration of melatonin (1 mg/kg) before modeling of acute hypoxia was accompanied by a decrease in the content of protein peroxidation products, an increase in the activity of the antioxidant enzymes, and normalization of the intensity of proteolysis.
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References
V. N. Anisimov, Melatonin: Its Role in the Body and its Use in Clinical Practice, Sistema, St. Petersburg (2007).
A. I. Arakov and I. M. Mosokhoev, “Modification of proteins by active oxygen and their degradation,” Biokhimiya, 54, No. 2, 179–186 (1989).
E. B. Arushanyan, “The antistress potential of epiphyseal melatonin,” in: Melatonin in Health and Disease, Moscow (2004), pp. 198–222.
E. B. Arushanyan, “The epiphyseal hormone melatonin in the combined pharmacotherapy of brain diseases and somatic pathology,” Eksperim. Klin. Farmakol., 74, No. 9, 39–45 (2011).
V. A. Baraboi and D. A. Sumkovoi, “Oxidant-Antioxidant Homeostasis in Health and Disease, Kiev (1997).
I. A. Zborovskaya and M. V. Bannikova, “The antioxidant system of the body and its importance in metabolism. Clinical aspects,” Vestn. Russ. Akad. Med. Nauk., No. 6, 53–59 (1995).
O. V. Goiko, Practical Application of Statistica for Analysis of Medical and Biological Data, Kiev (2004).
M. A. Korolyuk, L. I. Ivanova, I. G. Maiorov, and V. E. Tokarev, “A method for assay of catalase activity,” Lab. Delo, No. 1, 16–18 (1988).
V. Yu. Kulikov and L. B. Kim, An Oxygen Regime for Adaptation of Humans to the Far North, Novosibirsk (1987).
L. V. Pastushenkov, “Basic methods for assessing the protective action of antioxidants in experimental studies and their influences on metabolic processes in cells,” in: Pharmacological Correction of Hypoxic States, Meditsina, Moscow (1989), pp. 118–124.
L. V. Savchenkova, “Biochemical basis of the pathogenesis of hypoxic syndrome,” Ukr. Biokhimich. Alman., No. 1, 90–99 (1998).
R. D. Sinel’nikov and Ya. R. Sinel’nikov, Atlas of Human Anatomy, Meditsina, Moscow (1994).
Current Study and Clinical Investigation Methods of the Central Science Research Laboratory, Bukovina State Medical Academy, Bukovina State Medical Academy, Chernovtsy (2001).
I. A. Tregubova, V. A. Kosolapov, and A. S. Spasov, “Antioxidants: current status and perspectives,” Usp. Fiziol. Nauk., 43, No. 1, 75–94 (2012).
C. Chevari, I. Chaba, and I. Sekei, “The role of superoxide dismutase in oxidative processes in cells and a method for assaying it in biological materials,” Lab. Delo, No. 11, 678–681 (1985).
A. L. Dafre, N. S. Arteni, I. R. Siqueira, and C. A. Netto, “Perturbations in the thiol homeostasis following neonatal cerebral hypoxia-ischemia in rats,” Neurosci. Lett., 345, No. 1, 65–68 (2003).
A. Korkmaz and R. J. Reiter, “Epigenetic regulation: a new research area for melatonin?” J. Pineal. Res., 44, No. 1, 41–44 (2008).
D. Ozdemir, N. Uysal, S. Gonenc, et al., “Effect of melatonin on brain oxidative damage induced by traumatic brain injury in immature rats,” Physiol. Res., 10, 18–22 (2005).
C. Rodriguez, J. C. Mayo, R. M. Sainz, et al., “Regulation of antioxidant enzymes: a significant role for melatonin,” J. Pineal Res., 36, 1–9 (2004).
R. J. Reiter, D. X. Tan, and M. A. Pappolla, “Melatonin relieves the neural oxidative burden that contributes to dementias,” Ann. N. Y. Acad. Sci., 1035, 179–196 (2004).
R. J. Reiter, D. X. Tan, and M. P. Terron, “Melatonin: potential utility for improving public health,” TAF Prev. Med. Bull., 5, 131–158 (2006).
T. Zitnanova, K. Sumegova, and M. Simko, “Protein carbonyls as a biomarker of hypoxic stress,” Clin. Biochem., 40, No. 8, 567–570 (2007).
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 102, No. 12, pp. 1444–1452, December, 2016.
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Sopova, I.Y., Zamorskii, I.I. Effects of Melatonin on the Interaction between the Level of Accumulation of Oxidatively Modified Proteins, the Activity of Antioxidant Enzymes, and the State of Proteolysis in the Basal Ganglia of the Brain in Acute Hypoxia. Neurosci Behav Physi 48, 220–224 (2018). https://doi.org/10.1007/s11055-018-0555-y
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DOI: https://doi.org/10.1007/s11055-018-0555-y