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Peculiar Aspects in Influence of α1-Adrenoceptor Stimulation on Isolated Rat Heart

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The study examined the effect of α1-adrenoceptor stimulation with methoxamine on chronotropic function of isolated heart perfused ex vivo according to Langendorff and cardiac chronotropy in vivo. Stimulation of α1-adrenoceptors in isolated heart induced gradually developing bradycardia, which progressed during several minutes. Similar stimulation in vivo produced a short-term bradycardia probably terminated by the compensatory influences in the whole organism. Comparison of the data obtained in both experimental paradigms during α1-adrenoceptor stimulation revealed unidirectional changes in cardiac chronotropy characterized with time-related peculiarities.

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Authors and Affiliations

  1. Department of Human Health Protection, Kazan (Volga Region) Federal University, Kazan, the Republic of Tatarstan, Russia

    T. L. Zefirov, I. I. Khabibrakhmanov & N. I. Ziyatdinova

  2. Department of Normal Physiology, Kazan Federal Medical University, Kazan, the Republic of Tatarstan, Russia

    A. L. Zefirov

Authors
  1. T. L. Zefirov
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  2. I. I. Khabibrakhmanov
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  3. N. I. Ziyatdinova
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  4. A. L. Zefirov
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Correspondence to T. L. Zefirov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 7, pp. 7-10, July 2016

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Zefirov, T.L., Khabibrakhmanov, I.I., Ziyatdinova, N.I. et al. Peculiar Aspects in Influence of α1-Adrenoceptor Stimulation on Isolated Rat Heart. Bull Exp Biol Med 162, 4–6 (2016). https://doi.org/10.1007/s10517-016-3530-z

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  • DOI: https://doi.org/10.1007/s10517-016-3530-z

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