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Effect of ICa,L Blockade on Adrenergic Stimulation in Developing Heart

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Bulletin of Experimental Biology and Medicine Aims and scope

The effect of verapamil-induced blockade of L-type calcium ionic currents (ICa,L) on the action of non-selective adrenergic cardiac stimulation by norepinephrine was examined during different periods of early postnatal ontogeny. In 1-week-old rats, intravenous norepinephrine induced a short-term tachycardia both with and without preliminary injected verapamil. In 3-week-old rats, norepinephrine alone produced no chronotropic effect; in contrast, it induced a biphasic tachycardia in verapamil-treated rats. In 6- and 20-month-old rats, norepinephrine induced a short-term tachycardia, which could be prevented by verapamil. The age-related peculiarities of chronotropic action of non-selective adrenergic stimulation are indicative of the role of L-type calcium ionic channels in the development of sympathetic control over the heart.

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Authors and Affiliations

  1. Department of Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia

    T. L. Zefirov, A. M. Kuptsova, R. G. Biktemirova & N. I. Ziyatdinova

  2. Department of Normal Physiology, Kazan StateMedical University, Kazan, the Republic of Tatarstan, Russia

    A. L. Zefirov

Authors
  1. T. L. Zefirov
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  2. A. M. Kuptsova
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  3. R. G. Biktemirova
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  4. N. I. Ziyatdinova
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  5. A. L. Zefirov
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Correspondence to T. L. Zefirov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 6, pp. 696-699, June, 2016

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Zefirov, T.L., Kuptsova, A.M., Biktemirova, R.G. et al. Effect of ICa,L Blockade on Adrenergic Stimulation in Developing Heart. Bull Exp Biol Med 161, 746–748 (2016). https://doi.org/10.1007/s10517-016-3500-5

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  • DOI: https://doi.org/10.1007/s10517-016-3500-5

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