The effects of norepinephrine on the heart rate were studied in 1-, 3-, 6-, and 20-week-old rats before and after blockade of hyperpolarization-activated currents (If, Ih). In animals with mature sympathetic regulation of cardiac activity (6- and 20-week-old animals), If blockage decreased the severity of norepinephrine-induced tachycardia. In newborn rats lacking sympathetic innervation of the heart, norepinephrine only slightly affected heart rate before and after If blockage. In 3-week-old animals, If blockage after norepinephrine pretreatment increased tachycardia.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 7, pp. 6-8, July, 2013
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Ziyatdinova, N.I., Dement’eva, R.E., Khisamieva, L.I. et al. Age-Related Peculiarities of Adrenergic Regulation of Cardiac Chronotropic Action after If Blockage. Bull Exp Biol Med 156, 1–3 (2013). https://doi.org/10.1007/s10517-013-2262-6
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DOI: https://doi.org/10.1007/s10517-013-2262-6