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Generation of Reactive Oxygen Species in Peripheral Blood Lymphocytes of Patients with Prostate Cancer

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Bulletin of Experimental Biology and Medicine Aims and scope

The study revealed a two-fold elevation of ROS production in peripheral blood lymphocytes of the patients with prostate cancer (from 0.48±0.04 to 0.93±0.12 rel. units) together with significant variability of individual values. Hormone therapy had no effect on the mean and individual ROS levels. In contrast, organometallic cytostatics cisplatin and morfozol 2-fold increased ROS generation in lymphocytes of patients with prostate cancer above the enhanced level of this parameter determined by tumor growth.

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References

  1. N. Yu. Vorob’eva, A. V. Antonenko, and A. N. Osipov, Radiat. Biol. Radioekol., 51, No. 4, 451-456 (2011).

    Google Scholar 

  2. N. Yu. Vorob’eva, M. M. Antoshchina, I. I. Pelevina, et al., Vestn. Ross. Nauch. Center Rentgenoradiol., 4, No. 12, 24 (2012).

    Google Scholar 

  3. E. G. Gorozhanskaya, G. N. Zubrikhina, and S. P. Sviridova, Free Radical Oxidation and Basic Mechanisms of Antioxidant Defense in Norm and during Malignant Pathology [in Russian], Moscow (2010).

  4. A. K. Grekhova, L. B. Gorbacheva, N. A. Ivanova, et al., Biomed. Khimiya, 59, No. 1, 107-114 (2013).

    Article  CAS  Google Scholar 

  5. I. A. Efimenko, N. A. Ivanova, and B. V. Lokshin, Patent RF No. 2291872. Palladium Complexes with Heterocyclic Ligands, Byull. Izobret., No. 2, January 21, 2007.

  6. I. I. Pelevina, A. V. Aleshchenko, M. M. Antoshchina, et al., Radiat. Biol. Radioekol., 52, No. 2, 142-148 (2012).

    CAS  Google Scholar 

  7. I. I. Pelevina, A. V. Aleshchenko, M. M. Antoshchina, et al., Radiat. Biol. Radioekol., 49, No. 4, 419-424 (2009).

    CAS  Google Scholar 

  8. A. A. Savchenko, Yu. A. Dykhno, N. N. Kazakova, and M. V. Yatsinov, Sib. Onkol. Zh., No. 3, 9-13 (2010).

  9. T. Inokuma, M. Haraguchi, F. Fujita, et al., Hepatogastroenterology, 59, No. 120, 2480-2483 (2012).

    PubMed  Google Scholar 

  10. G. Y. Liou and P. Storz, Free Radic. Res., 44, No. 5, 479-496 (2010).

    Article  CAS  PubMed  Google Scholar 

  11. S. B. Nadin, L. M. Vargas-Roig, G. Drago, et al., Cancer Lett ., 239, No. 1, 84-97 (2006).

    Article  CAS  PubMed  Google Scholar 

  12. Y. Nakajima, K. Tsuruma, M. Shimazawa, et al., BMC Complement. Altern. Med., 9, 4 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia

    A. K. Grekhova & L. B. Gorbacheva

Authors
  1. A. K. Grekhova
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  2. L. B. Gorbacheva
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Correspondence to A. K. Grekhova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 11, pp. 666-668, November, 2015

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Grekhova, A.K., Gorbacheva, L.B. Generation of Reactive Oxygen Species in Peripheral Blood Lymphocytes of Patients with Prostate Cancer. Bull Exp Biol Med 160, 709–711 (2016). https://doi.org/10.1007/s10517-016-3256-y

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  • DOI: https://doi.org/10.1007/s10517-016-3256-y

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